ω-Hydroxy-DEET

Modify Date: 2024-01-04 15:48:52

ω-Hydroxy-DEET Structure
ω-Hydroxy-DEET structure
Common Name ω-Hydroxy-DEET
CAS Number 72236-22-7 Molecular Weight 207.26900
Density 1.082g/cm3 Boiling Point 383.1ºC at 760 mmHg
Molecular Formula C12H17NO2 Melting Point N/A
MSDS N/A Flash Point 185.5ºC

 Use of ω-Hydroxy-DEET


ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes[1][2][3].

 Names

Name N,N-diethyl-3-(hydroxymethyl)benzamide
Synonym More Synonyms

 ω-Hydroxy-DEET Biological Activity

Description ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes[1][2][3].
Related Catalog
In Vitro Hepatoma cell studies reveals that ω-Hydroxy-DEET (DHMB; 0.1-10 μg/mL; 48-72 hours) treatments decreases cellular proliferation[1].
In Vivo The metabolite ω-Hydroxy-DEET (DHMB) is extensively distributed following intravenous and topical skin administration of DEET in rats. The ω-Hydroxy-DEET appeared to be the major metabolite for DEET. Repeated once-daily topical application for 30 days lead to higher concentrations of ω-Hydroxy-DEET in the liver[1].
References

[1]. Daryl J Fediuk, et al. Metabolic disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and skin administration in rats. Int J Toxicol. Sep-Oct 2012;31(5):467-76.

[2]. Ryan C Lewis, et al. Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico. Environ Health. 2014 Nov 19;13:97.

[3]. Lu W, et al. DEET as a feeding deterrent. PLoS One. 2017 Dec 14;12(12):e0189243.

 Chemical & Physical Properties

Density 1.082g/cm3
Boiling Point 383.1ºC at 760 mmHg
Molecular Formula C12H17NO2
Molecular Weight 207.26900
Flash Point 185.5ºC
Exact Mass 207.12600
PSA 40.54000
LogP 1.66090
Index of Refraction 1.542

 Safety Information

Hazard Codes Xn

 Synonyms

N,N-diethyl-3-hydroxymethylphenylamide
Benzamide,N,N-diethyl-3-(hydroxymethyl)
N,N-Diethyl-m-hydroxymethylbenzamide
N,N-DIETHYL-3-HYDROXYMETHYL-BENZAMIDE