72236-22-7

72236-22-7 structure

Name: ω-Hydroxy-DEET
Chemical Name: N,N-diethyl-3-(hydroxymethyl)benzamide
CAS Number: 72236-22-7
Molecular Formula: C₁₂H₁₇NO₂
Molecular Weight: 207.26900
Catalog: Research Areas Infection
Create Date: 2016-06-07 14:00:08
Modify Date: 2024-01-04 15:48:52
ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes[1][2][3].

Name	N,N-diethyl-3-(hydroxymethyl)benzamide
Synonyms	N,N-diethyl-3-hydroxymethylphenylamide Benzamide,N,N-diethyl-3-(hydroxymethyl) N,N-Diethyl-m-hydroxymethylbenzamide N,N-DIETHYL-3-HYDROXYMETHYL-BENZAMIDE

Description	ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes[1][2][3].
Related Catalog	Research Areas >> Infection
In Vitro	Hepatoma cell studies reveals that ω-Hydroxy-DEET (DHMB; 0.1-10 μg/mL; 48-72 hours) treatments decreases cellular proliferation[1].
In Vivo	The metabolite ω-Hydroxy-DEET (DHMB) is extensively distributed following intravenous and topical skin administration of DEET in rats. The ω-Hydroxy-DEET appeared to be the major metabolite for DEET. Repeated once-daily topical application for 30 days lead to higher concentrations of ω-Hydroxy-DEET in the liver[1].
References	[1]. Daryl J Fediuk, et al. Metabolic disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and skin administration in rats. Int J Toxicol. Sep-Oct 2012;31(5):467-76. [2]. Ryan C Lewis, et al. Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico. Environ Health. 2014 Nov 19;13:97. [3]. Lu W, et al. DEET as a feeding deterrent. PLoS One. 2017 Dec 14;12(12):e0189243.

Hazard Codes	Xn