Procaterol

Modify Date: 2024-01-08 15:29:41

Procaterol structure	Common Name	Procaterol
	CAS Number	72332-33-3	Molecular Weight	290.36
	Density	1.191 g/cm3	Boiling Point	539.5ºC at 760 mmHg
	Molecular Formula	C₁₆H₂₂N₂O₃	Melting Point	170-173 °C(lit.)
	MSDS	N/A	Flash Point	N/A

Use of Procaterol

Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes[1].

Name	(R,S)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone
Synonym	More Synonyms

Description	Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	β2 adrenoceptor
References	[1]. Ikezono K, et al. Bronchodilating effect and anabolic effect of inhaled procaterol. Int J Sports Med. 2008 Nov;29(11):888-94. [2]. Tashimo H, et al. Effect of procaterol, a beta(2) selective adrenergic receptor agonist, on airway inflammation and hyperresponsiveness. Allergol Int. 2007 Sep;56(3):241-7. [3]. Koyama S, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75. [4]. Yamaya M, et al. Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Eur J Pharmacol. 2011 Jan 10;650(1):431-44. [5]. Komatani-Tamiya N, et al. Procaterol-stimulated increases in ciliary bend amplitude and ciliary beat frequency in mouse bronchioles. Cell Physiol Biochem. 2012;29(3-4):511-22.

Density	1.191 g/cm3
Boiling Point	539.5ºC at 760 mmHg
Melting Point	170-173 °C(lit.)
Molecular Formula	C₁₆H₂₂N₂O₃
Molecular Weight	290.36
Exact Mass	290.16300
PSA	85.35000
LogP	2.43460
Storage condition	-20°C
Water Solubility	3000 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC8295000

CHEMICAL NAME :: 2(1H)-Quinolinone, 8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl) -, (R*,S*)-(+-)-

CAS REGISTRY NUMBER :: 72332-33-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H22-N2-O3

MOLECULAR WEIGHT :: 290.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SYXUE3 Shenyang Yaoxueyuan Xuebao. Journal of Shenyang College of Pharmacy. (Shenyang Yaoxueyuan, 7, 2-duan, Wenhualu, Shenhequ, Shenyang, Peop. Rep. China) V.1- 1984- Volume(issue)/page/year: 3,259,1986

Hazard Codes	Xn
Risk Phrases	R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36/37-S37/39
WGK Germany	1
RTECS	IQ0220000
HS Code	29211190

HS Code	29211190

8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1h)-quinolinone(r*,s

EINECS 276-590-0

s*)-(+-)

PROCATEROL

ent-Florfenicol AMine-d3

(S)-N,N-DiMethyl-3-(1-naphthalenyl-d7-oxy)-3-(2-thienyl)propanaMine

MFCD01750015

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Procaterol
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Procaterol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Procaterol
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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