D2343

Modify Date: 2024-01-11 08:32:53

D2343 Structure
D2343 structure
Common Name D2343
CAS Number 72734-63-5 Molecular Weight 329.43300
Density 1.116g/cm3 Boiling Point 506.8ºC at 760 mmHg
Molecular Formula C20H27NO3 Melting Point N/A
MSDS N/A Flash Point 260.3ºC

 Use of D2343


D2343 is a β2-adrenoceptor agonist and also is an α1- adrenoceptor inhibitor.

 Names

Name 4-[1-hydroxy-2-[[4-(2-methoxyphenyl)-2-methylbutan-2-yl]amino]ethyl]phenol
Synonym More Synonyms

 D2343 Biological Activity

Description D2343 is a β2-adrenoceptor agonist and also is an α1- adrenoceptor inhibitor.
Related Catalog
Target

β2-adrenoceptor[1] α1- adrenoceptor[1]

In Vitro D2343 is a compound with about the same beta 2-adrenoceptor-agonist effect as Terbutaline and exhibiting in addition an alpha 1-receptor inhibitory activity[1]. The beta 2-agonistic and alpha 1-antagonistic drug D2343 inhibits the evoked contractions in a concentration related fashion with 50% effect at 9.6 μM[2].
In Vivo D2343 has been compared to the beta 2-agonist Terbutaline on oestrogenized uterine preparations from rat and rabbit and in myometrial strips from homo. D2343 has shown an ability to relax the uterine muscles to the same degree as Terbutaline or even more, especially when the two drugs are compared in preparations from rabbit and rat[1].
References

[1]. Olsson OA, et al. The effects in myometrial preparations of D2343, a beta 2-adrenoceptor agonist possessing alpha 1-receptor blocking qualities. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):391-7.

[2]. Olsson OA, et al. The effect of D2343 in transmurally stimulated rabbit isthmus muscle. Acta Pharmacol Toxicol (Copenh). 1985 May;56(5):427-30.

 Chemical & Physical Properties

Density 1.116g/cm3
Boiling Point 506.8ºC at 760 mmHg
Molecular Formula C20H27NO3
Molecular Weight 329.43300
Flash Point 260.3ºC
Exact Mass 329.19900
PSA 61.72000
LogP 3.82610
Index of Refraction 1.572
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA4801500
CHEMICAL NAME :
Benzenemethanol, 4-hydroxy-alpha-(((3-(2-methoxyphenyl)-1,1-dimethylpr opyl)amino)methyl)-
CAS REGISTRY NUMBER :
72734-63-5
LAST UPDATED :
199703
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H27-N-O3
MOLECULAR WEIGHT :
329.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0004835
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0004835
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0004835
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0004835

 Synonyms

d 2343
D2343