Darodipine

Modify Date: 2024-01-22 17:18:51

Darodipine Structure
Darodipine structure
Common Name Darodipine
CAS Number 72803-02-2 Molecular Weight 371.38700
Density 1.251g/cm3 Boiling Point 507.3ºC at 760 mmHg
Molecular Formula C19H21N3O5 Melting Point N/A
MSDS N/A Flash Point 260.6ºC

 Use of Darodipine


Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.

 Names

Name diethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Synonym More Synonyms

 Darodipine Biological Activity

Description Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.
Related Catalog
In Vivo Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon’s horn is the most sensitive to treatment with darodipine[1]. Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. A 6-month treatment (from the 18th to the 24th month of life) with an oral daily dose of 10 mg/kg of darodipine restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex[2].
Animal Admin Rats: Male Wistar rats are used. Twelve-month-old rats are left untreated and used as adult reference animals. Twenty-one-month-old rats are allotted randomly to two groups of 8 animals each. Rats of the first group receive an oral daily dose of 5 mg/kg of darodipine in drinking water. The animals of the second group are left untreated and served as a control group. Rats of these two groups are allowed to survive for 6 months, until 27 months of age (old rats). Darodipine-treated rats have water consumption determined every second day and body weight determined weekly[1].
References

[1]. Amenta F, et al. Effect of long-term treatment with the dihydropyridine-type calcium channel blocker darodipine(PY 108-068) on the cerebral capillary network in aged rats. Mech Ageing Dev. 1995 Jan 31;78(1):27-37.

[2]. Vega JA, et al. Effect of treatment with the dihydropyridine-type calcium antagonist darodipine (PY 108-068) on the expression of neurofilament protein immunoreactivity in the cerebellar cortex of aged rats. Mech Ageing Dev. 1994 Aug;75(2):169-77.

 Chemical & Physical Properties

Density 1.251g/cm3
Boiling Point 507.3ºC at 760 mmHg
Molecular Formula C19H21N3O5
Molecular Weight 371.38700
Flash Point 260.6ºC
Exact Mass 371.14800
PSA 103.55000
LogP 2.91260
Index of Refraction 1.566

 Synthetic Route

~78%

Darodipine Structure

Darodipine

CAS#:72803-02-2

Literature: Baraldi, Patricia Tambarussi; Noel, Timothy; Wang, Qi; Hessel, Volker Tetrahedron Letters, 2014 , vol. 55, # 13 p. 2090 - 2092

~54%

Darodipine Structure

Darodipine

CAS#:72803-02-2

Literature: Ohno; Komatsu; Mizukoshi; Ichihara; Nakamura; Morishima; Sumita Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1589 - 1606

~%

Darodipine Structure

Darodipine

CAS#:72803-02-2

Literature: Ohno; Komatsu; Mizukoshi; Ichihara; Nakamura; Morishima; Sumita Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1589 - 1606

~%

Darodipine Structure

Darodipine

CAS#:72803-02-2

Literature: Ohno; Komatsu; Mizukoshi; Ichihara; Nakamura; Morishima; Sumita Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1589 - 1606

~%

Darodipine Structure

Darodipine

CAS#:72803-02-2

Literature: Ohno; Komatsu; Mizukoshi; Ichihara; Nakamura; Morishima; Sumita Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1589 - 1606

~50%

Darodipine Structure

Darodipine

CAS#:72803-02-2

Literature: Ohno; Komatsu; Mizukoshi; Ichihara; Nakamura; Morishima; Sumita Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1589 - 1606

~%

Darodipine Structure

Darodipine

CAS#:72803-02-2

Literature: Ohno; Komatsu; Mizukoshi; Ichihara; Nakamura; Morishima; Sumita Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1589 - 1606

 Synonyms

Darodipinum
Dazodipine
Darodipino
DARODIPINE
PY 108-068
Dazodipin
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