Dapiprazole Hydrochloride

Modify Date: 2024-01-04 18:08:40

Dapiprazole Hydrochloride Structure
Dapiprazole Hydrochloride structure
Common Name Dapiprazole Hydrochloride
CAS Number 72822-13-0 Molecular Weight 361.91
Density 1.2±0.1 g/cm3 Boiling Point 538.9±60.0 °C at 760 mmHg
Molecular Formula C19H28ClN5 Melting Point N/A
MSDS N/A Flash Point 279.7±32.9 °C

 Use of Dapiprazole Hydrochloride


Dapiprazole hydrochloride is a potent α-adrenergic blocking drug, which is used to reverse mydriasis after eye examination.(1) It inhibits amphetamine toxicity and alcohol and morphine withdrawal syndromes, produces sedation, blocks conditioned avoidance reflexes and reduces the response to noxious stimuli.(2) The orally administrated daily dose varied from 30 to 90 mg.

 Names

Name 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine,hydrochloride
Synonym More Synonyms

 Dapiprazole Hydrochloride Biological Activity

Description Dapiprazole hydrochloride is a potent α-adrenergic blocking drug, which is used to reverse mydriasis after eye examination.(1) It inhibits amphetamine toxicity and alcohol and morphine withdrawal syndromes, produces sedation, blocks conditioned avoidance reflexes and reduces the response to noxious stimuli.(2) The orally administrated daily dose varied from 30 to 90 mg.
Related Catalog
References

[1]. Ramesh T et al.Development and validation of a stability-indicating RP-HPLC assay method and stress degradation studies ondapiprazole. J Chromatogr Sci. 2013 Oct;51(9):856-60.

[2]. Marx-Gross S et al. Brimonidine versus dapiprazole: Influence on pupil size at various illumination levels. J Cataract Refract Surg. 2005 Jul;31(7):1372-6.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 538.9±60.0 °C at 760 mmHg
Molecular Formula C19H28ClN5
Molecular Weight 361.91
Flash Point 279.7±32.9 °C
PSA 37.19000
LogP 2.44
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.658
Storage condition -20℃

 Synonyms

Rev-Eyes
Dapiprazole hydrochloride
AF 2139
1,2,4-Triazolo[4,3-a]pyridine, 5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-
5,6,7,8-Tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-1,2,4-triazolo[4,3-a]pyridine
Dapiprazole
Dapiprazole hydrochloride (USAN)
Dapiprazole HCl
3-{2-[4-(2-Methylphenyl)piperazin-1-yl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
3-{2-[4-(2-Methylphenyl)-1-piperazinyl]ethyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
5,6,7,8-Tetrahydro-3-[2-(4-o-tolyl-1-piperazinyl)ethyl]-s-triazolo[4,3-a]pyridine
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