Psoromic Acid

Modify Date: 2024-01-02 22:33:40

Psoromic Acid structure	Common Name	Psoromic Acid
	CAS Number	7299-11-8	Molecular Weight	358.30
	Density	1.483 g/cm3	Boiling Point	641.7ºC at 760 mmHg
	Molecular Formula	C₁₈H₁₄O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	237ºC

Use of Psoromic Acid

Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC50 value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition[1][2].

Name	10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid
Synonym	More Synonyms

Description	Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC50 value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	IC50: 1.3 µM (RabGGTase)[1]
References	[1]. Deraeve C, et al. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc. 2012 May 2;134(17):7384-91. [2]. Behera BC, et al. Antioxidative and cardiovascular-protective activities of metabolite usnic acid and psoromic acid produced by lichen species Usnea complanata under submerged fermentation. Pharm Biol. 2012 Aug;50(8):968-79.

Density	1.483 g/cm3
Boiling Point	641.7ºC at 760 mmHg
Molecular Formula	C₁₈H₁₄O₈
Molecular Weight	358.30
Flash Point	237ºC
Exact Mass	358.06900
PSA	119.36000
LogP	2.85320
Index of Refraction	1.658

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP3082200

CHEMICAL NAME :: 11H-Dibenzo(b,e)(1,4)dioxepin-6-carboxylic acid, 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl- 11-oxo-

CAS REGISTRY NUMBER :: 7299-11-8

LAST UPDATED :: 198308

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 9,55,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 9,55,1982

methyl psoromate

CAS#:60441-77-2

Psoromic Acid

CAS#:7299-11-8

Literature: Shanghai Institute of Materia Medica, Chinese Academy of Sciences Patent: EP2199295 A1, 2010 ; Location in patent: Page/Page column 18 ;

Precursor 1
CAS#:60441-77-2 methyl psoromate
DownStream 0

Parellic acid

Psoromsaeure

psoromic acid

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Psoromic Acid
Price: ￥2988.0/10mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Psoromic Acid
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxodibenzo[b,f]1,4-dioxepin-6-carboxylic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Psoromic Acid

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