Atractylenolide III

Modify Date: 2024-01-02 10:45:39

Atractylenolide III Structure
Atractylenolide III structure
 Common Name Atractylenolide III
CAS Number 73030-71-4 Molecular Weight 248.318
Density 1.2±0.1 g/cm3 Boiling Point 424.6±45.0 °C at 760 mmHg
Molecular Formula C15H20O3 Melting Point 200-201ºC
MSDS USA Flash Point 181.1±21.5 °C

 Use of Atractylenolide III


Atractylenolide III is a major component of Atractylodes rhizome can induce apoptosis of the lung carcinoma cells.IC50 value:Target: Anticancer natural compoundin vitro: ATL-III inhibited cell growth, increased lactate dehydrogenase release and modulated cell cycle on human lung carcinoma A549 cells. ALT-III induced the activation of caspase-3 and caspase-9 and cleavage of poly-(ADP)-ribose polymerase. ATL-III induced the release of cytochrome c, upregulation of bax expression, and translocation of apoptosis-inducing factor [1]. Atractylenolide II did not show cytoprotective effects, but oral administration of atractylenolide III dose-dependently prevented ethanol-induced PRGM cell death and cell membrane damage. The EC50 values were 0.27 and 0.34 mm, respectively [2]. Against adult D. pteronyssinus, atractylenolide III (LD50, 73.8 mg/m2) and atractylon (72.1 mg/m2) were eight times more active than Deet and 2.5-fold more toxic than dibutyl phthalate [3].in vivo: In the in-vivo assay, atractylenolide III 10 mg/kg significantly reduced 70% ethanol-induced Wistar rat gastric ulcer. Atractylenolide III could inhibit matrix metalloproteinase (MMP)-2 and MMP-9 expression through upregulation of tissue inhibitors of metalloproteinase from the gastric ulcerated tissues [2].

 Names

Name Atractylenolide III
Synonym More Synonyms

 Atractylenolide III Biological Activity

Description Atractylenolide III is a major component of Atractylodes rhizome can induce apoptosis of the lung carcinoma cells.IC50 value:Target: Anticancer natural compoundin vitro: ATL-III inhibited cell growth, increased lactate dehydrogenase release and modulated cell cycle on human lung carcinoma A549 cells. ALT-III induced the activation of caspase-3 and caspase-9 and cleavage of poly-(ADP)-ribose polymerase. ATL-III induced the release of cytochrome c, upregulation of bax expression, and translocation of apoptosis-inducing factor [1]. Atractylenolide II did not show cytoprotective effects, but oral administration of atractylenolide III dose-dependently prevented ethanol-induced PRGM cell death and cell membrane damage. The EC50 values were 0.27 and 0.34 mm, respectively [2]. Against adult D. pteronyssinus, atractylenolide III (LD50, 73.8 mg/m2) and atractylon (72.1 mg/m2) were eight times more active than Deet and 2.5-fold more toxic than dibutyl phthalate [3].in vivo: In the in-vivo assay, atractylenolide III 10 mg/kg significantly reduced 70% ethanol-induced Wistar rat gastric ulcer. Atractylenolide III could inhibit matrix metalloproteinase (MMP)-2 and MMP-9 expression through upregulation of tissue inhibitors of metalloproteinase from the gastric ulcerated tissues [2].
Related Catalog
References

[1]. Kang TH, et al. Atractylenolide III, a sesquiterpenoid, induces apoptosis in human lung carcinoma A549 cells via mitochondria-mediated death pathway. Food Chem Toxicol. 2011 Feb;49(2):514-9.

[2]. Wang KT, et al. Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo. J Pharm Pharmacol. 2010 Mar;62(3):381-8.

[3]. Kim HK, et al. Toxicity of atractylon and atractylenolide III Identified in Atractylodes ovata rhizome to Dermatophagoides farinae and Dermatophagoides pteronyssinus. J Agric Food Chem. 2007 Jul 25;55(15):6027-31.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 424.6±45.0 °C at 760 mmHg
Melting Point 200-201ºC
Molecular Formula C15H20O3
Molecular Weight 248.318
Flash Point 181.1±21.5 °C
Exact Mass 248.141251
PSA 46.53000
LogP 2.36
Appearance of Characters white to off-white
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.558
Storage condition 2-8°C
Water Solubility methanol: soluble1mg/mL, clear, colorless

 Safety Information

RIDADR NONH for all modes of transport

 Articles4

More Articles
Sesquiterpenoids from Atractylodes macrocephala act as farnesoid X receptor and progesterone receptor modulators.

Bioorg. Med. Chem. Lett. 22 , 2326-2329, (2012)

Two sesquiterpenoids, atractylenolide II and III, were isolated and identified from Atractylodes macrocephala (Asteraceae) to be subsequently evaluated for their activity against farnesoid X receptor ...

Targeting of the Sonic Hedgehog pathway by atractylenolides promotes chondrogenic differentiation of mesenchymal stem cells.

Biol. Pharm. Bull. 35 , 1328-1335, (2012)

Molecules that enhance chondrogenic differentiation in mesenchymal stem cells (MSCs) were identified and isolated using an in vitro Gli reporter gene assay in MSCs incorporating a Sonic Hedgehog (Shh)...

Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study.

PLoS ONE 10 , e0133159, (2015)

Rikkunshito, a traditional Japanese (Kampo) medicine, has been used to treat upper gastrointestinal disorders such as functional dyspepsia and gastroesophageal reflux. This study investigated the expo...

 Synonyms

Atractylenolide III
Naphtho(2,3-b)furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-, (4aS,8aR,9aS)-
codonolactone
ATRACTYLENOLIDE
8-HYDROXYASTEROLIDE
(4aS,8aR,9aS)-9a-Hydroxy-3,8a-dimethyl-5-methylene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one
Naphtho[2,3-b]furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-, (4aS,8aR,9aS)-
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Atractylenolide III suppliers

Price: ￥1295/10mg

Reference only. check more Atractylenolide III price

Related Compounds: More...
Atractylenolide II
73069-14-4
Atractylenolide I
73069-13-3
atractylenolide IV
147396-00-7
Cerium(III) Bis(trifluoromethanesulfonyl)imide
1046099-39-1
iron(iii) citrate hydrate, 98
334024-15-6
Fe(III)(PP)Br
14319-22-3
indium(III) tris(diethyldithiocarbamate)
15741-07-8
praseodymium(iii) acetylacetonate dihydrate
22203-89-0
thuliium(iii) sulfate
20731-62-8
1-[2-Chloro-5-(trifluoromethyl)pyridin-3-yl]-2,2-difluorocyclopropan-1-amine
2228200-63-1
2-(4-Bromo-5-chlorothiophen-2-yl)piperidine
2228728-23-0
rac-[(1R,3R)-3-(2-bromo-5-methoxyphenyl)-2,2-dimethylcyclopropyl]methanamine
2227836-39-5
[2-(6-Chloro-2-methoxypyridin-3-yl)ethyl](methyl)amine
2229084-29-9
tert-butyl N-[2-(3-amino-1-fluoropropyl)-5-bromophenyl]carbamate
2229611-53-2
5-(2-bromo-6-methoxyphenyl)-1-methyl-1H-pyrazol-4-amine
2229624-77-3
O-{[1-(3-bromo-5-methoxypyridin-4-yl)cyclopropyl]methyl}hydroxylamine
2228545-41-1
tert-butyl N-[1-amino-3-(6-chloropyridin-2-yl)propan-2-yl]carbamate
2229534-51-2
3-(4-Chloro-2-methoxypyridin-3-yl)-2,2-difluoropropanoic acid
2229107-78-0
3-(6-Chloro-5-methylpyridin-3-yl)butanoic acid
2228484-86-2
Chemsrc provides Atractylenolide III(CAS#:73030-71-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Atractylenolide III are included as well.>> amp version: Atractylenolide III

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved