Anagyrine hydrochloride

Modify Date: 2024-04-03 00:55:12

Anagyrine hydrochloride structure	Common Name	Anagyrine hydrochloride
	CAS Number	74195-83-8	Molecular Weight	280.79
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₂₁ClN₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Anagyrine hydrochloride

Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR, and Anagyrine hydrochloride can directly, without metabolism, desensitize nAChR[1][2][3].

Name	Anagyrine hydrochloride

Description	Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR, and Anagyrine hydrochloride can directly, without metabolism, desensitize nAChR[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vitro	Anagyrine 在 SH-SY5Y 和 TE-671 两种细胞系中均充当部分激动剂， EC50 值分别为 4.2 和 231 μM。 Anagyrine 是 nAChR 的脱敏剂，在 SH-SY5Y 和 TE-671 细胞中的 DC50 值分别为 6.9 和 139 μM[3]。
References	[1]. Schmeller T, et al. Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors. J Nat Prod. 1994 Sep;57(9):1316-9. [2]. Matsuda, K., et al. Nematicidal activities of (–)-N-methylcytisine and (–)-anagyrine from Sophora flavescens against pine wood nematodes. Agr. BioI. Chem. 53(8), 2287-2288 (1989). [3]. Green BT, et al. Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle. Res Vet Sci. 2017 Dec;115:195-200.

Molecular Formula	C₁₅H₂₁ClN₂O
Molecular Weight	280.79

Anagyrine hydrochloride

Use of Anagyrine hydrochloride

Names

Anagyrine hydrochloride Biological Activity

Chemical & Physical Properties