LY125180

Modify Date: 2024-03-05 16:39:22

LY125180 structure	Common Name	LY125180
	CAS Number	74515-39-2	Molecular Weight	305.84
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₄ClNO	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LY125180

LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with Ki values of 0.06 μM, 2.2 μM and 2.5 μM respectively[1].

Name	N,N-dimethyl-3-(4-methylphenoxy)-1-phenylpropan-1-amine,hydrochloride
Synonym	More Synonyms

Description	LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with Ki values of 0.06 μM, 2.2 μM and 2.5 μM respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Wong DT, et al. N,N-Dimethyl-alpha-[2-(p-tolyloxy)ethyl]benzylamine hydrochloride (LY125180). Effects on serotonin uptake and serotonin synthesis in rat brain in vitro and in vivo. Biochem Pharmacol. 1980 Mar 15;29(6):935-41.

Molecular Formula	C₁₈H₂₄ClNO
Molecular Weight	305.84
Exact Mass	305.15500
PSA	12.47000
LogP	4.86880

N,N-dimethyl-3-(4-methylphenoxy)-1-phenylpropan-1-amine hydrochloride

LY125180

Use of LY125180

Names

LY125180 Biological Activity

Chemical & Physical Properties

Synonyms