C12-Ceramide

Modify Date: 2024-01-05 11:05:22

C12-Ceramide Structure
C12-Ceramide structure
Common Name C12-Ceramide
CAS Number 74713-60-3 Molecular Weight 481.79
Density 0.9±0.1 g/cm3 Boiling Point 636.1±55.0 °C at 760 mmHg
Molecular Formula C30H59NO3 Melting Point N/A
MSDS N/A Flash Point 338.5±31.5 °C

 Use of C12-Ceramide


C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1].

 Names

Name N-dodecanoylsphingosine
Synonym More Synonyms

 C12-Ceramide Biological Activity

Description C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1].
Related Catalog
In Vitro C12-Ceramide (1 μM; 24-72 h) enhances the liposomal Doxorubicin toxicity in MDA-MB-231 cells[1].
References

[1]. He X, et, al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314(1):116-20.

[2]. Øverbye A, et, al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8(44):76921-76934.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 636.1±55.0 °C at 760 mmHg
Molecular Formula C30H59NO3
Molecular Weight 481.79
Flash Point 338.5±31.5 °C
Exact Mass 481.449493
PSA 69.56000
LogP 11.21
Vapour Pressure 0.0±4.3 mmHg at 25°C
Index of Refraction 1.481
Storage condition -20°C

 MSDS

Name: N-Lauroyl-D-Erythro-Sphingosine Synthetical 99+% Material Safety Data Sheet
Synonym: Ceramide C12
CAS: 74713-60-3
Section 1 - Chemical Product MSDS Name:N-Lauroyl-D-Erythro-Sphingosine Synthetical 99+% Material Safety Data Sheet
Synonym:Ceramide C12

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
74713-60-3 N-Lauroyl-D-Erythro-Sphingosine 99+% unlisted
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a dry area. Deep freeze (below -20C).

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 74713-60-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white to off-white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C30H59NO3
Molecular Weight: 481.80

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable.
Conditions to Avoid:
Incompatible materials, dust generation.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 74713-60-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
N-Lauroyl-D-Erythro-Sphingosine - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 74713-60-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 74713-60-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 74713-60-3 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Safety Phrases S24/25
HS Code 2924199090

 Synthetic Route

~%

C12-Ceramide Structure

C12-Ceramide

CAS#:74713-60-3

Literature: Journal of the American Chemical Society, , vol. 80, p. 4657

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

N-[(2S,3R,4E)-1,3-Dihydroxy-4-octadecen-2-yl]dodecanamide
N-((1S,2R)-2-hydroxy-1-hydroxymethyl-heptadec-3t-enyl)-lauramide
Dodecanamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-
Laurylsphingosine
D-erthro-2-Lauroylamino-octadec-4t-en-1,3-diol
C12 Ceramide
N-((1S,2R)-2-Hydroxy-1-hydroxymethyl-heptadec-3t-enyl)-lauramid
N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]dodecanamide
N-(dodecanoyl)ceramide
Dodecyl sphingosine
N-Laurylsphingosine
N-Lauroylsphingosine
Cer(d18:1/12:0)
N-lauroyl-D-erythro-Sphingosine
N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]dodecanamide
N-(lauroyl)ceramide
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