7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL

Modify Date: 2024-01-17 18:26:20

7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL structure	Common Name	7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL
	CAS Number	747408-78-2	Molecular Weight	271.142
	Density	1.4±0.1 g/cm3	Boiling Point	367.8±37.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₂Cl₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	176.2±26.5 °C

Use of 7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL

PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2].

Name	PBT-1033
Synonym	More Synonyms

Description	PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	PB 1033 displays antibacterial activity against S. uberis, with a MIC value of 14.5 μM[2]. PBT2 (1, 3 and 7.5 μM, 6 h) protects neurons against glutamate-induced excitotoxicity[3]. PBT2 (10 μM, 1 or 6 h) reduces NMDAR-mediated Ca2+ flux in mouse cortical neurons[3]. PBT2 (0-10 μM, 1 h) increases GSK3α/β phosphorylation in SH-SY5Y cells[4]. PBT2 (20 μM, 1 h) prevents the formation of Zn-induced protease resistant Aβ aggregates[5]. Western Blot Analysis[4] Cell Line: SH-SY5Y cells Concentration: 0-10 μM Incubation Time: 1 h Result: Increased in cellular levels of GSK3α/β phosphorylated at the inhibitory serine 21/9 residue (ser21/9 on GSK3α/β).
In Vivo	PBT 1033 (30 mg/kg/d, p.o., 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease[5]. Animal Model: Female Tg2576 mice[5] Dosage: 30 mg/kg/d Administration: Oral administration, 11 days Result: Increased hippocampal apical spine density, basal spine density.

Density	1.4±0.1 g/cm3
Boiling Point	367.8±37.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₂Cl₂N₂O
Molecular Weight	271.142
Flash Point	176.2±26.5 °C
Exact Mass	270.032654
LogP	3.51
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.654

5,7-Dichloro-2-[(dimethylamino)methyl]-8-quinolinol

Q7K6GJQ4O4

8-Quinolinol, 5,7-dichloro-2-[(dimethylamino)methyl]-

PBT-1033

MFCD30749371

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PB1033
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: PBT 1033
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥1400/5 mg

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