Bisdionin C

Modify Date: 2024-01-12 11:03:14

Bisdionin C Structure
Bisdionin C structure
Common Name Bisdionin C
CAS Number 74857-22-0 Molecular Weight 400.39200
Density N/A Boiling Point N/A
Molecular Formula C17H20N8O4 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Bisdionin C


Bisdionin C is a potent GH18 chitinases inhibitor, with an IC50 of 0.2 μM for A. fumigatus ChiB1 (AfChiB1). Bisdionin C inhibits HCHT (human macrophage chitotriosidase) and acidic mammalian chitinase (AMCase) with IC50s of 8.3 and 3.4 μM, respectively[1].

 Names

Name 1,1'-trimethylenebis[theobromine]
Synonym More Synonyms

 Bisdionin C Biological Activity

Description Bisdionin C is a potent GH18 chitinases inhibitor, with an IC50 of 0.2 μM for A. fumigatus ChiB1 (AfChiB1). Bisdionin C inhibits HCHT (human macrophage chitotriosidase) and acidic mammalian chitinase (AMCase) with IC50s of 8.3 and 3.4 μM, respectively[1].
Related Catalog
Target

GH18 Chitinases[1]

References

[1]. Schüttelkopf AW, et al. Bisdionin C-a rationally designed, submicromolar inhibitor of family 18 chitinases. ACS Med Chem Lett. 2011;2(6):428-432. Published 2011 Mar 23.

 Chemical & Physical Properties

Molecular Formula C17H20N8O4
Molecular Weight 400.39200
Exact Mass 400.16100
PSA 123.64000

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport

 Synonyms

1,3-Bis-[theobrominyl-(1)]-propan
bisdionin C
3,7,3',7'-tetramethyl-3,7,3',7'-tetrahydro-1,1'-propane-1,3-diyl-bis-purine-2,6-dione
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