YC-001
Modify Date: 2024-01-01 18:44:09
YC-001 structure
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Common Name | YC-001 | ||
|---|---|---|---|---|
| CAS Number | 748778-73-6 | Molecular Weight | 282.766 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 494.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C12H7ClO2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 252.7±28.7 °C | |
Use of YC-001YC-001 is a novel pharmacological chaperone of rod photoreceptor opsin, rescues the transport of multiple rod opsin mutants in mammalian cells; demonstrates micromolar potency and efficacy greater than 9-cis-retinal with lower cytotoxicity; binds to bovine rod opsin with an EC50 (8.7 uM) similar to 9-cis-retinal, improves the glycosylation of the P23H-opsin mutant; YC-001 is an inverse agonist and antagonist of rod opsin that non-competitively antagonizes rod opsin signaling, delays isorhodopsin pigment regeneration; protects Abca4 -/- Rdh8 -/- mice from bright light-induced retinal degeneration. |
| Name | 4-(5-Chloro-2-thienyl)-3-(2-thienyl)-2(5H)-furanone |
|---|---|
| Synonym | More Synonyms |
| Description | YC-001 is a novel pharmacological chaperone of rod photoreceptor opsin, rescues the transport of multiple rod opsin mutants in mammalian cells; demonstrates micromolar potency and efficacy greater than 9-cis-retinal with lower cytotoxicity; binds to bovine rod opsin with an EC50 (8.7 uM) similar to 9-cis-retinal, improves the glycosylation of the P23H-opsin mutant; YC-001 is an inverse agonist and antagonist of rod opsin that non-competitively antagonizes rod opsin signaling, delays isorhodopsin pigment regeneration; protects Abca4 -/- Rdh8 -/- mice from bright light-induced retinal degeneration. |
|---|---|
| References | References 1. Chen Y, et al. Nat Commun. 2018 May 17;9(1):1976. View Related Products by Target Other Targets |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 494.2±45.0 °C at 760 mmHg |
| Molecular Formula | C12H7ClO2S2 |
| Molecular Weight | 282.766 |
| Flash Point | 252.7±28.7 °C |
| Exact Mass | 281.957611 |
| LogP | 3.35 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.686 |
| 4-(5-Chloro-2-thienyl)-3-(2-thienyl)-2(5H)-furanone |
| 2(5H)-Furanone, 4-(5-chloro-2-thienyl)-3-(2-thienyl)- |
| MFCD03948015 |