TLSC702
Modify Date: 2024-09-18 19:50:46
TLSC702 structure
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Common Name | TLSC702 | ||
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| CAS Number | 748786-57-4 | Molecular Weight | 325.382 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 547.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H15NO3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 284.7±32.9 °C | |
Use of TLSC702TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM; inhibits the proliferation of human leukemia HL-60 cells and induces apoptosis in a dose-dependent manner; more significantly inhibits the proliferation of human lung cancer NCI-H522 cells, which highly express GLO I, than that of GLO I lower-expressing human lung cancer NCI-H460 cells. |
| Name | (3Z)-3-(1,3-Benzothiazol-2-yl)-4-(4-methoxyphenyl)-3-butenoic acid |
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| Synonym | More Synonyms |
| Description | TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM; inhibits the proliferation of human leukemia HL-60 cells and induces apoptosis in a dose-dependent manner; more significantly inhibits the proliferation of human lung cancer NCI-H522 cells, which highly express GLO I, than that of GLO I lower-expressing human lung cancer NCI-H460 cells. |
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| References | References 1. Takasawa R, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4337-42. 2. Takasawa R, et al. Biol Pharm Bull. 2016;39(5):869-73. 3. Shimada N, et al. Arch Biochem Biophys. 2018 Jan 15;638:1-7. View Related Products by Target Other Targets |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 547.2±60.0 °C at 760 mmHg |
| Molecular Formula | C18H15NO3S |
| Molecular Weight | 325.382 |
| Flash Point | 284.7±32.9 °C |
| Exact Mass | 325.077271 |
| LogP | 5.44 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.696 |
| MFCD06660558 |
| 2-Benzothiazolepropanoic acid, β-[(4-methoxyphenyl)methylene]-, (βZ)- |
| (3Z)-3-(1,3-Benzothiazol-2-yl)-4-(4-methoxyphenyl)-3-butenoic acid |