748786-57-4

748786-57-4 structure

Name: TLSC702
Chemical Name: (3Z)-3-(1,3-Benzothiazol-2-yl)-4-(4-methoxyphenyl)-3-butenoic acid
CAS Number: 748786-57-4
Molecular Formula: C₁₈H₁₅NO₃S
Molecular Weight: 325.382
Create Date: 2020-01-11 16:21:53
Modify Date: 2024-09-18 19:50:46
TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM; inhibits the proliferation of human leukemia HL-60 cells and induces apoptosis in a dose-dependent manner; more significantly inhibits the proliferation of human lung cancer NCI-H522 cells, which highly express GLO I, than that of GLO I lower-expressing human lung cancer NCI-H460 cells.

Name	(3Z)-3-(1,3-Benzothiazol-2-yl)-4-(4-methoxyphenyl)-3-butenoic acid
Synonyms	MFCD06660558 2-Benzothiazolepropanoic acid, β-[(4-methoxyphenyl)methylene]-, (βZ)- (3Z)-3-(1,3-Benzothiazol-2-yl)-4-(4-methoxyphenyl)-3-butenoic acid

Description	TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM; inhibits the proliferation of human leukemia HL-60 cells and induces apoptosis in a dose-dependent manner; more significantly inhibits the proliferation of human lung cancer NCI-H522 cells, which highly express GLO I, than that of GLO I lower-expressing human lung cancer NCI-H460 cells.
References	References 1. Takasawa R, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4337-42. 2. Takasawa R, et al. Biol Pharm Bull. 2016;39(5):869-73. 3. Shimada N, et al. Arch Biochem Biophys. 2018 Jan 15;638:1-7. View Related Products by Target Other Targets