(D-Ser2)-Leu-Enkephalin-Thr

Modify Date: 2024-01-08 18:25:28

(D-Ser2)-Leu-Enkephalin-Thr Structure
(D-Ser2)-Leu-Enkephalin-Thr structure
 Common Name (D-Ser2)-Leu-Enkephalin-Thr
CAS Number 75644-90-5 Molecular Weight 686.753
Density 1.3±0.1 g/cm3 Boiling Point 1163.0±65.0 °C at 760 mmHg
Molecular Formula C33H46N6O10 Melting Point N/A
MSDS N/A Flash Point 657.2±34.3 °C

 Use of (D-Ser2)-Leu-Enkephalin-Thr


DSLET ([D-Ser2, Leu5, Thr6]-enkephalin) is a highly specific agonist of the δ-receptor. DSLET is an enkephalin-related peptide selectively bound to the δ opioid receptor[1][2].

 Names

Name dslet
Synonym More Synonyms

 (D-Ser2)-Leu-Enkephalin-Thr Biological Activity

Description DSLET ([D-Ser2, Leu5, Thr6]-enkephalin) is a highly specific agonist of the δ-receptor. DSLET is an enkephalin-related peptide selectively bound to the δ opioid receptor[1][2].
Related Catalog
Target

δ Opioid Receptor/DOR

In Vitro DSLET (0.1-1000 μM) 以剂量依赖性方式抑制霍乱毒素 (CT; HY-P1446) 诱导的 cAMP 生成[1]。
References

[1]. J L Nano, et al. Characterization of delta-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line. Pflugers Arch. 2000 Mar;439(5):547-54.  

[2]. C S Goodchild, et al. Antinociception by intrathecal midazolam involves endogenous neurotransmitters acting at spinal cord delta opioid receptors. Br J Anaesth. 1996 Dec;77(6):758-63.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 1163.0±65.0 °C at 760 mmHg
Molecular Formula C33H46N6O10
Molecular Weight 686.753
Flash Point 657.2±34.3 °C
Exact Mass 686.327515
PSA 269.51000
LogP 1.09
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.592
Storage condition -20°C

 Synthetic Route

N-(tert-butyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serylglycyl-L-phenylalanyl-L-leucyl-O-tert-butyl-L-threonine structure

N-(tert-butylox...

CAS#:78537-18-5

~90%

(D-Ser2)-Leu-Enkephalin-Thr Structure

(D-Ser2)-Leu-En...

CAS#:75644-90-5

Literature: Gacel, Gilles; Fournie-Zaluski, Marie-Claude; Fellion, Etienne; Roques, Bernard P. Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1119 - 1124
Boc-Tyr-OH structure

Boc-Tyr-OH

CAS#:3978-80-1

~%

(D-Ser2)-Leu-Enkephalin-Thr Structure

(D-Ser2)-Leu-En...

CAS#:75644-90-5

Literature: Gacel, Gilles; Fournie-Zaluski, Marie-Claude; Fellion, Etienne; Roques, Bernard P. Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1119 - 1124
N-(tert-butyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serine structure

N-(tert-butylox...

CAS#:78537-15-2

~%

(D-Ser2)-Leu-Enkephalin-Thr Structure

(D-Ser2)-Leu-En...

CAS#:75644-90-5

Literature: Gacel, Gilles; Fournie-Zaluski, Marie-Claude; Fellion, Etienne; Roques, Bernard P. Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1119 - 1124
N-(tert-butyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serine methyl ester structure

N-(tert-butylox...

CAS#:78537-13-0

~%

(D-Ser2)-Leu-Enkephalin-Thr Structure

(D-Ser2)-Leu-En...

CAS#:75644-90-5

Literature: Gacel, Gilles; Fournie-Zaluski, Marie-Claude; Fellion, Etienne; Roques, Bernard P. Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1119 - 1124
N-(tert-butyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serylglycyl-L-phenylalanyl-L-leucine structure

N-(tert-butylox...

CAS#:78565-55-6

~%

(D-Ser2)-Leu-Enkephalin-Thr Structure

(D-Ser2)-Leu-En...

CAS#:75644-90-5

Literature: Gacel, Gilles; Fournie-Zaluski, Marie-Claude; Fellion, Etienne; Roques, Bernard P. Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1119 - 1124
N-(tert-butyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serylglycyl-L-phenylalanyl-L-leucine methyl ester structure

N-(tert-butylox...

CAS#:78537-16-3

~%

(D-Ser2)-Leu-Enkephalin-Thr Structure

(D-Ser2)-Leu-En...

CAS#:75644-90-5

Literature: Gacel, Gilles; Fournie-Zaluski, Marie-Claude; Fellion, Etienne; Roques, Bernard P. Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1119 - 1124
N-(tert-butyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serylglycyl-L-phenylalanyl-L-leucyl-O-tert-butyl-L-threonine methyl ester structure

N-(tert-butylox...

CAS#:78537-17-4

~%

(D-Ser2)-Leu-Enkephalin-Thr Structure

(D-Ser2)-Leu-En...

CAS#:75644-90-5

Literature: Gacel, Gilles; Fournie-Zaluski, Marie-Claude; Fellion, Etienne; Roques, Bernard P. Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1119 - 1124

 Synonyms

M.W. 686.90 C33H46N6O10
L-Threonine, L-tyrosyl-D-serylglycyl-L-phenylalanyl-L-leucyl-
D-Ser2,Leu5,Thr6-enkephalin
L-Tyrosyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine
Dislet
Dstle
TYR-D-SER-GLY-PHE-LEU-THR
2-Ser-Thr-Leu-enkephalin
[D-Ser2] Leu-Enkephalin-Thr
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