Cyclo(-Arg-Ala-Asp-D-Phe-Lys) trifluoroacetate salt

Modify Date: 2024-01-01 20:52:05

Cyclo(-Arg-Ala-Asp-D-Phe-Lys) trifluoroacetate salt Structure
Cyclo(-Arg-Ala-Asp-D-Phe-Lys) trifluoroacetate salt structure
Common Name Cyclo(-Arg-Ala-Asp-D-Phe-Lys) trifluoroacetate salt
CAS Number 756500-23-9 Molecular Weight 617.69700
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C28H43N9O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cyclo(-Arg-Ala-Asp-D-Phe-Lys) trifluoroacetate salt


Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis. Sequence: Cyclo(Ala-Asp-Phe-Lys-Arg).

 Names

Name Cyclo(L-alanyl-L-α-aspartyl-D-phenylalanyl-L-lysyl-L-arginyl)
Synonym More Synonyms

  Biological Activity

Description Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis. Sequence: Cyclo(Ala-Asp-Phe-Lys-Arg).
Related Catalog
Target

Integrin[1].

In Vitro Cyclo(RADfK) is a negative control for the cyclo (-RGDfK-), the RGD peptide. RGD peptides are modulators of cell adhesion and are recognized by several members of the integrin family[1].
References

[1]. Srivatsan A, et al. Conjugation of cRGD peptide to chlorophyll a based photosensitizer (HPPH) alters its pharmacokinetics withenhanced tumor-imaging and photosensitizing (PDT) efficacy. Mol Pharm. 2011 Aug 1;8(4):1186-1197.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C28H43N9O7
Molecular Weight 617.69700
Exact Mass 617.32900
PSA 270.72000
LogP -2.75
Index of Refraction 1.659
Storage condition -20°C

 Synonyms

Cyclo(L-alanyl-L-α-aspartyl-D-phenylalanyl-L-lysyl-L-arginyl)
cyclo (Arg-Ala-Asp-d-Phe-Lys)
Cyclo(RADfK)
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