Mal-amido-PEG8-NHS ester

Modify Date: 2024-04-05 11:45:56

Mal-amido-PEG8-NHS ester Structure
Mal-amido-PEG8-NHS ester structure
Common Name Mal-amido-PEG8-NHS ester
CAS Number 756525-93-6 Molecular Weight 689.70500
Density N/A Boiling Point N/A
Molecular Formula C30H47N3O15 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mal-amido-PEG8-NHS ester


Mal-amido-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Mal-PEG8-NHS
Synonym More Synonyms

 Mal-amido-PEG8-NHS ester Biological Activity

Description Mal-amido-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C30H47N3O15
Molecular Weight 689.70500
Exact Mass 689.30100
PSA 204.00000
Storage condition 2-8°C

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

α-Maleimidopropionyl-ω-succinimidyl-8(ethylene glycol)
succinimidyl[(N-maleimidopropionamido)octaethyleneglycol]ester
Alpha-Maleimidopropionyl-ω-succinimidyl-8(ethylene glycol)
[3-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-propionylamino]-ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-propionic acid-2,5-dioxo-pyrrolidin-1-yl ester
Maleimide-PEG8-NHS Ester
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