Pentoxyverine

Modify Date: 2024-01-02 16:46:27

Pentoxyverine structure	Common Name	Pentoxyverine
	CAS Number	77-23-6	Molecular Weight	333.465
	Density	1.0±0.1 g/cm3	Boiling Point	435.5±30.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₃₁NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	217.2±24.6 °C

Use of Pentoxyverine

Pentoxyverine (Carbetapentane) is a sigma-1 receptor agonist, with a Ki of 75 nM on guinea-pig brain membranes. Pentoxyverine is a centrally-acting cough suppressant with antimuscarinic and anticonvulsant properties. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance[1][2][3][4].

Name	Pentoxyverine
Synonym	More Synonyms

Description	Pentoxyverine (Carbetapentane) is a sigma-1 receptor agonist, with a Ki of 75 nM on guinea-pig brain membranes. Pentoxyverine is a centrally-acting cough suppressant with antimuscarinic and anticonvulsant properties. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance[1][2][3][4].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
Target	Ki: 75 nM (sigma-1 receptor)[4]
In Vitro	Pentoxyverine competitive binds to [3H]-pentazocine-labelled sites on guinea-pig brain membranes, with a Ki of 75 nM[4].
In Vivo	Pentoxyverine (1-5 mg/kg; a single i.p.) inhibits citric-acid-induced cough in guinea-pigs[4].
References	[1]. Mohamed SH, et, al. Extraction-free spectrophotometric assay of the antitussive drug pentoxyverine citrate using sulfonephthalein dyes. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Nov 5;222:117186. [2]. Tortella FC, et, al. Dextromethorphan and carbetapentane: centrally acting non-opioid antitussive agents with novel anticonvulsant properties. Brain Res. 1986 Sep 24;383(1-2):314-8. [3]. Calderon SN, et, al. Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands. J Med Chem. 1994 Jul 22;37(15):2285-91. [4]. Brown C, et, al. Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Br J Pharmacol. 2004 Jan;141(2):233-40.

Density	1.0±0.1 g/cm3
Boiling Point	435.5±30.0 °C at 760 mmHg
Molecular Formula	C₂₀H₃₁NO₃
Molecular Weight	333.465
Flash Point	217.2±24.6 °C
Exact Mass	333.230408
PSA	38.77000
LogP	3.29
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.517

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY3450000

CHEMICAL NAME :: Cyclopentanecarboxylic acid, 1-phenyl-, 2-(2-(diethylamino)ethoxy)ethyl ester

CAS REGISTRY NUMBER :: 77-23-6

BEILSTEIN REFERENCE NO. :: 2299701

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H31-N-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 9,446,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 9,446,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 9,446,1957

Safety Phrases	S26-S36
WGK Germany	3
HS Code	2921300090

α-Phenylcyclope...

CAS#:17380-62-0

2-(a-diethylami...

CAS#:140-82-9

Pentoxyverine

CAS#:77-23-6

Literature: US2842585 , ;

Precursor 2
CAS#:17380-62-0 α-Phenylcyclope... CAS#:140-82-9 2-(a-diethylami...
DownStream 0

HS Code	2921300090
Summary	2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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Cyclopentanecarboxylic acid, 1-phenyl-, 2-[2-(diethylamino)ethoxy]ethyl ester

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EINECS 201-014-1

2-[2-(Diethylamino)ethoxy]ethyl 1-phenylcyclopentanecarboxylate

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Pentoxiverine

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Pentoxyverine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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DC Chemicals Limited
China
Product Name: Carbetapentane
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pentoxyverine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥550/10 mM * 1 mL in DMSO

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Pentoxyverine

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