Chloroxine

Modify Date: 2024-01-13 11:50:21

Chloroxine Structure
Chloroxine structure
Common Name Chloroxine
CAS Number 773-76-2 Molecular Weight 214.048
Density 1.5±0.1 g/cm3 Boiling Point 354.7±37.0 °C at 760 mmHg
Molecular Formula C9H5Cl2NO Melting Point 178-180 °C(lit.)
MSDS Chinese USA Flash Point 168.3±26.5 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of Chloroxine


Chloroxine is a synthetic antibacterial compound that is effective in the treatment of dandruff and seborrheic dermatitis when incorporated in a shampoo.Target: AntibacterialChloroxine is an antibacterial drug. Oral formulations are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis, as used in shampoos and dermal creams like. Chloroxine has bacteriostatic, fungistatic and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigella and Trichomonads.

 Names

Name chloroxine
Synonym More Synonyms

 Chloroxine Biological Activity

Description Chloroxine is a synthetic antibacterial compound that is effective in the treatment of dandruff and seborrheic dermatitis when incorporated in a shampoo.Target: AntibacterialChloroxine is an antibacterial drug. Oral formulations are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis, as used in shampoos and dermal creams like. Chloroxine has bacteriostatic, fungistatic and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigella and Trichomonads.
Related Catalog
References

[1]. http://www.drugs.com/cons/chloroxine-topical.html

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 354.7±37.0 °C at 760 mmHg
Melting Point 178-180 °C(lit.)
Molecular Formula C9H5Cl2NO
Molecular Weight 214.048
Flash Point 168.3±26.5 °C
Exact Mass 212.974823
PSA 33.12000
LogP 3.75
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.702
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VC5350000
CHEMICAL NAME :
8-Quinolinol, 5,7-dichloro-
CAS REGISTRY NUMBER :
773-76-2
BEILSTEIN REFERENCE NO. :
0153606
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C9-H5-Cl2-N-O
MOLECULAR WEIGHT :
214.05

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,141,1994

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37/39-S25-S22
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS VC5350000
HS Code 2933499090

 Synthetic Route

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Chloroxine Structure

Chloroxine

CAS#:773-76-2

Literature: Dalton Transactions, , vol. 42, # 6 p. 2023 - 2034

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Chloroxine Structure

Chloroxine

CAS#:773-76-2

Literature: Chemische Berichte, , vol. 21, p. 2979,2983

~%

Chloroxine Structure

Chloroxine

CAS#:773-76-2

Literature: Chemische Berichte, , vol. 21, p. 2979,2983

~%

Chloroxine Structure

Chloroxine

CAS#:773-76-2

Literature: Journal of the Indian Chemical Society, , vol. 22, p. 171

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Chloroxine Structure

Chloroxine

CAS#:773-76-2

Literature: Journal of the Indian Chemical Society, , vol. 21, p. 354,356

~%

Chloroxine Structure

Chloroxine

CAS#:773-76-2

Detail
Literature: Chemische Berichte, , vol. 85, p. 104,106

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles7

More Articles
Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides.

Org. Lett. 16(3) , 864-7, (2014)

A one-step transformation of heterocyclic N-oxides to 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles is described. The success of this broad-scope methodology hinges on the combination of cop...

Reverse-phase high-performance liquid chromatographic determination of halogenated 8-hydroxyquinoline compounds in pharmaceuticals and bulk drugs.

J. Pharm. Sci. 73(10) , 1430-3, (1984)

A reverse-phase high-performance liquid chromatographic (HPLC) method was developed for determining iodochlorhydroxyquin, 5,7-dichloro-8-hydroxyquinoline, and 5,7-diiodo-8-hydroxyquinoline in creams, ...

Effects of chlorhexidine, iodine, and 5,7-dichloro-8-hydroxyquinoline on the bacterial composition of rat plaque in vivo.

Caries Res. 18(5) , 440-6, (1984)

 Synonyms

5,7-Dichloro-8-quinolinol
5,7-Dichloro-8-hydroxyquinoline
EINECS 212-258-3
Chloroxine
5,7-dichloroquinolin-8-ol
8-Quinolinol, 5,7-dichloro-
MFCD00006786
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