Cetirizine D8

Modify Date: 2024-01-03 12:26:57

Cetirizine D8 Structure
Cetirizine D8 structure
Common Name Cetirizine D8
CAS Number 774596-22-4 Molecular Weight 469.85900
Density N/A Boiling Point N/A
Molecular Formula C21H17D8ClN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cetirizine D8


Cetirizine D8 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

 Names

Name Cetirizine-D8
Synonym More Synonyms

 Cetirizine D8 Biological Activity

Description Cetirizine D8 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
Related Catalog
Target

H1 receptor

References

[1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055•1080, 1993.

[2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5.

[3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.

 Chemical & Physical Properties

Molecular Formula C21H17D8ClN2O3
Molecular Weight 469.85900
Exact Mass 468.15900
PSA 53.01000
LogP 4.62800

 Synonyms

[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl-2,2,3,3,5,5,6,6-d8]ethoxy]acetic acid
Acetic acid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl-2,2,3,3,5,5,6,6-d8]ethoxy]-
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