Apoptosis Activator 2
Modify Date: 2024-01-02 19:37:55
Apoptosis Activator 2 structure
|
Common Name | Apoptosis Activator 2 | ||
|---|---|---|---|---|
| CAS Number | 79183-19-0 | Molecular Weight | 306.143 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 470.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C15H9Cl2NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 238.4±31.5 °C | |
Use of Apoptosis Activator 2Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.IC50 value: 4-9 uM(Leukemia origin cells)[1]Target: Apoptosis activatorin vitro: Apoptosis Activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Apoptosis Activator 2 exerted a cytostatic effect on the majority of cell lines tested, inhibiting cell growth by 50–100% at 10 μM in 40 of 48 cell lines tested. Apoptosis Activator 2 exerted a cytotoxic effect, reducing the cell numbers by 10–50% and 50–100% in four and eight cell lines, respectively, from the initial levels when tested at 10 μM. At 100 μM Apoptosis Activator 2 exhibited 100% cytotoxicity in virtually all cell lines, an effect that may be due to nonspecific toxicity. Of the cancer cell lines tested in the panel, cell lines of lymphoid origin (CCRF-CEM, MOLT-4, and Jurkat) were quite sensitive to compound 2-induced killing, with IC50 values ranging from 4 to 9 μM [1]. Apoptosis Activator 2 is a potent and selective carboxylesterase inhibitor with Ki of 67/31/65 nM for hiCE/hCE/rCE respectively, also has less inhibition on AChE/BChE with Ki of 48.2/12.6 uM [2]. |
| Name | 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione |
|---|---|
| Synonym | More Synonyms |
| Description | Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.IC50 value: 4-9 uM(Leukemia origin cells)[1]Target: Apoptosis activatorin vitro: Apoptosis Activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Apoptosis Activator 2 exerted a cytostatic effect on the majority of cell lines tested, inhibiting cell growth by 50–100% at 10 μM in 40 of 48 cell lines tested. Apoptosis Activator 2 exerted a cytotoxic effect, reducing the cell numbers by 10–50% and 50–100% in four and eight cell lines, respectively, from the initial levels when tested at 10 μM. At 100 μM Apoptosis Activator 2 exhibited 100% cytotoxicity in virtually all cell lines, an effect that may be due to nonspecific toxicity. Of the cancer cell lines tested in the panel, cell lines of lymphoid origin (CCRF-CEM, MOLT-4, and Jurkat) were quite sensitive to compound 2-induced killing, with IC50 values ranging from 4 to 9 μM [1]. Apoptosis Activator 2 is a potent and selective carboxylesterase inhibitor with Ki of 67/31/65 nM for hiCE/hCE/rCE respectively, also has less inhibition on AChE/BChE with Ki of 48.2/12.6 uM [2]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 470.6±55.0 °C at 760 mmHg |
| Molecular Formula | C15H9Cl2NO2 |
| Molecular Weight | 306.143 |
| Flash Point | 238.4±31.5 °C |
| Exact Mass | 305.001038 |
| PSA | 37.38000 |
| LogP | 3.42 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.671 |
| Storage condition | Store at RT |
| Safety Phrases | 24/25 |
|---|---|
| RIDADR | 3077 |
| HS Code | 29145090 |
| 1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]- |
| Apoptosis Activator 2 |
| Apoptosis Activator II |
| Tocris-2098 |
| 1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione |