Hydrazinecarboselenoamide,N,N-dimethyl-2-[1-(2-pyridinyl)ethylidene]-

Modify Date: 2024-09-12 10:10:54

Hydrazinecarboselenoamide,N,N-dimethyl-2-[1-(2-pyridinyl)ethylidene]- Structure
Hydrazinecarboselenoamide,N,N-dimethyl-2-[1-(2-pyridinyl)ethylidene]- structure
Common Name Hydrazinecarboselenoamide,N,N-dimethyl-2-[1-(2-pyridinyl)ethylidene]-
CAS Number 79514-49-1 Molecular Weight 270.21300
Density N/A Boiling Point N/A
Molecular Formula C10H15N4Se Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Hydrazinecarboselenoamide,N,N-dimethyl-2-[1-(2-pyridinyl)ethylidene]-


Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization[1].

 Names

Name 1-λ1-selanyl-N,N-dimethyl-N'-[(E)-1-pyridin-2-ylethylideneamino]methanimidamide
Synonym More Synonyms

  Biological Activity

Description Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization[1].
Related Catalog
References

[1]. Zaynab Al-Eisawi, et al. Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization. J Med Chem. 2016 Jan 14;59(1):294-312.  

 Chemical & Physical Properties

Molecular Formula C10H15N4Se
Molecular Weight 270.21300
Exact Mass 271.04600
PSA 40.52000
LogP 0.71610

 Synthetic Route

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Hydrazinecarboselenoamide,N,N-dimethyl-2-[1-(2-pyridinyl)ethylidene]- Structure

Hydrazinecarbos...

CAS#:79514-49-1

Literature: Klayman; Scovill; Bartosevich; Mason European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 317 - 320

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Hydrazinecarboselenoamide,N,N-dimethyl-2-[1-(2-pyridinyl)ethylidene]- Structure

Hydrazinecarbos...

CAS#:79514-49-1

Literature: Klayman; Scovill; Bartosevich; Mason European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 317 - 320

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

2-acetylpyridine-N,N-dimethylselenosemicarbazone
2-acetylpyridine 4,4-dimethyl-3-selenosemicarbazone
2-Acetylpyridine 4,4-dimethylselenosemicarbazone