ACRIFLAVINE structure
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Common Name | ACRIFLAVINE | ||
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CAS Number | 8048-52-0 | Molecular Weight | 259.73 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C14H14ClN3 | Melting Point | 179-181 °C | |
MSDS | Chinese USA | Flash Point | N/A | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of ACRIFLAVINEAcriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic. |
Name | acriflavine |
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Synonym | More Synonyms |
Description | Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic. |
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Related Catalog | |
In Vitro | Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines[1]. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells[2]. |
In Vivo | Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization[1]. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance[2]. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis[3]. |
Animal Admin | Mice: CML mice are treated daily with acriflavine (8 mg/kg) or PBS via intraperitoneal injection, for 10 days starting from day 7 after bone marrow transplantation[2]. |
References |
Melting Point | 179-181 °C |
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Molecular Formula | C14H14ClN3 |
Molecular Weight | 259.73 |
PSA | 120.85000 |
LogP | 3.86310 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302-H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xn:Harmful;N:Dangerousfortheenvironment; |
Risk Phrases | R22;R37/38;R41;R50/53 |
Safety Phrases | S26-S39-S60-S61 |
RIDADR | UN 3077 9/PG 3 |
WGK Germany | 3 |
RTECS | AR9660000 |
HS Code | 38249064 |
HS Code | 38249064 |
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Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.
Free Radic. Res. 48(10) , 1206-17, (2014) Excessive expansion of white adipose tissue leads to hypoxia which is considered as a key factor responsible for adipose tissue dysfunction in obesity. Hypoxia induces inflammation, insulin resistance... |
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Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.
Proc. Natl. Acad. Sci. U. S. A. 112 , 9112-7, (2015) Kinetoplastid parasites cause lethal diseases in humans and animals. The kinetoplast itself contains the mitochondrial genome, comprising a huge, complex DNA network that is also an important drug tar... |
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The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents.
Antimicrob. Agents Chemother. 59(3) , 1534-41, (2015) Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase th... |
ACRIFLAVINE |
EUFLAVINE |
3,6-Diamino-10-methylacridinium chloride - 3,6-acridinediamine (1:1:1) |
3,6-Diamino-10-methylacridinium Chloride mixt with 3,6-Acridine Diamine |
3,6-Diamino-10-methylacridinium chloride 3,6-acridinediamine (1:1:1) |
diacrid |
3,6-Diamino-10-methylacridinium chloride 3,6-acridinediamine (1:1) |
flavipin |
Trypaflavine |
Acridinium, 3,6-diamino-10-methyl-, chloride, mixt. with 3,6-acridinediamine |
gonacin |
3,6-Diamino-10-methylacridinium chloride - acridine-3,6-diamine (1:1:1) |
flavine |
Neutroflavine |
EUFLAVIN |
angiflan |
Neutral Acriflavine |
flavisept |
isravin |
MFCD00064307 |