Grossamide

Modify Date: 2024-01-01 19:23:57

Grossamide structure	Common Name	Grossamide
	CAS Number	80510-06-1	Molecular Weight	624.68
	Density	1.3±0.1 g/cm3	Boiling Point	934.8±65.0 °C at 760 mmHg
	Molecular Formula	C₃₆H₃₆N₂O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	519.2±34.3 °C

Use of Grossamide

Grossamide is a natural product that can be isolated from fructus cannabis, the dried fruit of Cannabis sativa L.. Grossamide has anti-neuroinflammatory effects[1].

Name	Grossamide
Synonym	More Synonyms

Description	Grossamide is a natural product that can be isolated from fructus cannabis, the dried fruit of Cannabis sativa L.. Grossamide has anti-neuroinflammatory effects[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	Grossamide downregulates LPS-mediated production of inflammatory molecules[1]. Grossamide (0-20 μM, 1 h) inhibits the mRNA levels of TNF-α and IL-6 in a dose-dependent manner, inhibits LPS-induced NF-κB activation, and inhibits LPS-induced TLR4 and MyD88 expression without cytotoxicity[1]. RT-PCR[1] Cell Line: BV-2 microglia cell Concentration: 0, 10, 15, and 20 μM Incubation Time: 1 h and co-cultured with LPS (100 ng/mL) for another 6 h Result: Inhibited the mRNA levels of TNF-α and IL-6 in a dose-dependent manner. Western Blot Analysis[1] Cell Line: BV-2 microglia cell Concentration: 0, 10, 15, and 20 μM Incubation Time: 1 h followed by LPS (100 ng/mL) stimulation for 1 h or 24 h Result: Inhibited LPS-induced phosphorylation of IκBα and significantly reduced phosphorylation of NF-κB p65 levels. Dose-dependently decreased the expression of TLR4 and MyD88. Cell Viability Assay[1] Cell Line: BV-2 microglia cell Concentration: 0, 10, 15, and 20 μM Incubation Time: 1 h and co-cultured in the absence or presence of 100 ng/ mL LPS for 24 h Result: Had no cytotoxicity.
References	[1]. Luo Q, et al. Anti-neuroinflammatory effects of grossamide from hemp seed via suppression of TLR-4-mediated NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells. Mol Cell Biochem. 2017 Apr;428(1-2):129-137.

Density	1.3±0.1 g/cm3
Boiling Point	934.8±65.0 °C at 760 mmHg
Molecular Formula	C₃₆H₃₆N₂O₈
Molecular Weight	624.68
Flash Point	519.2±34.3 °C
Exact Mass	624.247192
PSA	146.58000
LogP	2.98
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.654

Hazard Codes	Xi

feruloyltyramine

CAS#:65646-26-6

~20%

Grossamide

CAS#:80510-06-1

Literature: Yoshihara, Teruhiko; Yamaguchi, Katsuyoshi; Takamatsu, Seiji; Sakamura, Sadao Agricultural and Biological Chemistry, 1981 , vol. 45, # 11 p. 2593 - 2598

N-trans-Feruloy...

CAS#:66648-43-9

Grossamide

CAS#:80510-06-1

Literature: Yoshihara, Teruhiko; Yamaguchi, Katsuyoshi; Takamatsu, Seiji; Sakamura, Sadao Agricultural and Biological Chemistry, 1981 , vol. 45, # 11 p. 2593 - 2598

Precursor 2
CAS#:65646-26-6 feruloyltyramine CAS#:66648-43-9 N-trans-Feruloy...
DownStream 0

2-(4-Hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-5-[(1E)-3-{[2-(4-hydroxyphenyl)ethyl]amino}-3-oxo-1-propen-1-yl]-7-methoxy-2,3-dihydro-1-benzofuran-3-carboxamide

trans-divinyl ethylene oxide

3-Benzofurancarboxamide, 2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-5-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-7-methoxy-

trans-2,3-Divinyloxirane

trans-grossamide