(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

Modify Date: 2024-01-02 17:06:49

(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione Structure
(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione structure
Common Name (S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
CAS Number 80758-83-4 Molecular Weight 376.36200
Density 1.54g/cm3 Boiling Point 817ºC at 760 mmHg
Molecular Formula C21H16N2O5 Melting Point N/A
MSDS N/A Flash Point 447.9ºC

 Names

Name camptothecin-7-aldehyde
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.54g/cm3
Boiling Point 817ºC at 760 mmHg
Molecular Formula C21H16N2O5
Molecular Weight 376.36200
Flash Point 447.9ºC
Exact Mass 376.10600
PSA 98.49000
LogP 1.89210
Index of Refraction 1.744

 Synthetic Route

~%

(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione Structure

(S)-11-Formy-4-...

CAS#:80758-83-4

Literature: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. Patent: WO2009/16068 A1, 2009 ; Location in patent: Page/Page column 8 ;

~68%

(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione Structure

(S)-11-Formy-4-...

CAS#:80758-83-4

Literature: Miyasaka, Tadashi; Sawada, Seigo; Nokata, Ken-ichiro Heterocycles, 1981 , vol. 16, # 10 p. 1719 - 1721

~19%

(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione Structure

(S)-11-Formy-4-...

CAS#:80758-83-4

Literature: Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

~90%

(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione Structure

(S)-11-Formy-4-...

CAS#:80758-83-4

Literature: Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

~%

(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione Structure

(S)-11-Formy-4-...

CAS#:80758-83-4

Literature: Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

~67%

(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione Structure

(S)-11-Formy-4-...

CAS#:80758-83-4

Literature: Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

~68%

(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione Structure

(S)-11-Formy-4-...

CAS#:80758-83-4

Literature: Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

~%

(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione Structure

(S)-11-Formy-4-...

CAS#:80758-83-4

Literature: Ricci, Antonio; Marinello, Jessica; Bortolus, Marco; Sanchez, Albert; Grandas, Anna; Pedroso, Enrique; Pommier, Yves; Capranico, Giovanni; Maniero, Anna Lisa; Zagotto, Giuseppe Journal of Medicinal Chemistry, 2011 , vol. 54, # 4 p. 1003 - 1009

 Synonyms

camptothecin-7-carbaldehyde
7-formyl CPT
coptothecin-7-carbaldehyde
(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
(20S)-camptothecin-7-carboxaldehyde
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde,4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-,(S)
7-formyl camptothecin
(S)-4-Ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde