Resolvin D2
Modify Date: 2024-01-02 16:25:25
Resolvin D2 structure
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Common Name | Resolvin D2 | ||
|---|---|---|---|---|
| CAS Number | 810668-37-2 | Molecular Weight | 376.487 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 609.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C22H32O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 336.3±28.0 °C | |
Use of Resolvin D2Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3]. |
| Name | Resolvin D2 |
|---|---|
| Synonym | More Synonyms |
| Description | Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3]. |
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| Related Catalog | |
| Target |
TRP Channel[3] |
| In Vivo | Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions[1]. Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression[2]. Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain[3]. Animal Model: Adult CD1 mice (male, 8–10 weeks)[3] Dosage: 10 ng Administration: Intraplantar administration Result: Inhibited inflammatory pain. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 609.2±55.0 °C at 760 mmHg |
| Molecular Formula | C22H32O5 |
| Molecular Weight | 376.487 |
| Flash Point | 336.3±28.0 °C |
| Exact Mass | 376.224976 |
| PSA | 97.99000 |
| LogP | 2.70 |
| Vapour Pressure | 0.0±4.0 mmHg at 25°C |
| Index of Refraction | 1.559 |
| Resolvin D2 |
| 4,8,10,12,14,19-Docosahexaenoic acid, 7,16,17-trihydroxy-, (4Z,7S,8E,10Z,12E,14E,16R,17S,19Z)- |
| (4Z,7S,8E,10Z,12E,14E,16R,17S,19Z)-7,16,17-Trihydroxy-4,8,10,12,14,19-docosahexaenoic acid |