Nafamostat

Modify Date: 2024-01-03 23:04:51

Nafamostat Structure
Nafamostat structure
Common Name Nafamostat
CAS Number 81525-10-2 Molecular Weight 347.371
Density 1.4±0.1 g/cm3 Boiling Point 637.2±65.0 °C at 760 mmHg
Molecular Formula C19H17N5O2 Melting Point N/A
MSDS N/A Flash Point 339.1±34.3 °C

 Use of Nafamostat


Nafamostat is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation; is also a possible complement inhibitor.Target: Serine ProteaseTranilast (FUT-175) is an antiallergic drug for bronchial asthma. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. It has also been investigated for use as an antiproliferative drug on drug-eluting stents.A 20-40 mg/h dose of FUT-175 prolonged coagulation time sufficiently in the instrumental blood of the extracorporeal circuit but not in the systemic blood. Its anticoagulant activity decreased immediately after hemodialysis. Therefore, we could manage all patients without any bleeding trouble during hemodialysis with FUT-175 as an anticoagulant. Although there were side effects of FUT-175, such as nausea, vomiting, itching and eruption, they were not serious, and FUT-175 could be administered without interruption. FUT-175 seems to be useful as an anticoagulant during hemodialysis for patients susceptible to bleeding.

 Names

Name nafamostat mesylate
Synonym More Synonyms

 Nafamostat Biological Activity

Description Nafamostat is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation; is also a possible complement inhibitor.Target: Serine ProteaseTranilast (FUT-175) is an antiallergic drug for bronchial asthma. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. It has also been investigated for use as an antiproliferative drug on drug-eluting stents.A 20-40 mg/h dose of FUT-175 prolonged coagulation time sufficiently in the instrumental blood of the extracorporeal circuit but not in the systemic blood. Its anticoagulant activity decreased immediately after hemodialysis. Therefore, we could manage all patients without any bleeding trouble during hemodialysis with FUT-175 as an anticoagulant. Although there were side effects of FUT-175, such as nausea, vomiting, itching and eruption, they were not serious, and FUT-175 could be administered without interruption. FUT-175 seems to be useful as an anticoagulant during hemodialysis for patients susceptible to bleeding.
Related Catalog
References

[1]. Ikehara S, et al. Effect of FUT-175, a new synthetic protease inhibitor, on the development of lupus nephritis in (NZB x NZW) F1 mice. Immunology. 1985 Aug;55(4):595-600.

[2]. Pak K, et al. Effectiveness of FUT-175, protease inhibitor, as an anticoagulant to hemodialysis. Hinyokika Kiyo. 1988 Jun;34(6):1077-81.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 637.2±65.0 °C at 760 mmHg
Molecular Formula C19H17N5O2
Molecular Weight 347.371
Flash Point 339.1±34.3 °C
Exact Mass 347.138214
PSA 138.07000
LogP 1.93
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.694
Storage condition 2-8℃

 Synonyms

6-Carbamimidoyl-2-naphthyl 4-carbamimidamidobenzoate
6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate
Nafamostat Dimethanesulfonate
NAFAMOSTAT MESILATE
Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester
6-Amidino-2-naphthyl-4-guanidinobenzoate
Futhan
6-AMIDINO-2-NAPHTHYL-4-GUANIDINOENZOATE,MESYLATE
Nafamstat
Nafamostat
6-carbamimidoylnaphthalen2-yl 4-(diaminomethyleneamino) benzoate
FUT-175
6-Amidino-2-naphthyl 4-guanidinobenzoate
NafamostatMesilateBase
4-[(Aminoiminomethyl)amino]benzoic Acid 6-(Aminoiminomethyl)-2-naphthalenyl Ester
4-Guanidinobenzoic acid 6-amidino-2-naphtyl ester
Top Suppliers:I want be here



Get all suppliers and price by the below link:

Nafamostat suppliers


Price: $60/10mg

Reference only. check more Nafamostat price