Visnagin

Modify Date: 2024-01-10 18:06:14

Visnagin structure	Common Name	Visnagin
	CAS Number	82-57-5	Molecular Weight	230.216
	Density	1.3±0.1 g/cm3	Boiling Point	378.2±42.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₀O₄	Melting Point	139-142 °C
	MSDS	N/A	Flash Point	182.5±27.9 °C

Use of Visnagin

Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles[1][2].

Name	4-methoxy-7-methylfuro[3,2-g]chromen-5-one
Synonym	More Synonyms

Description	Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	Visnagin (10 µM; for 4, 8, 16, 24 h) induces CYP1A1 transcription in HepG2 cells[1]. Visnagin (10 µM; for 16 h) elevates CYP1B1 gene expression in an aryl hydrocarbon receptor (AHR)-dependent manner, whereas MNF (3’-methoxy-4’-nitroflavone; 20 µM; pre-treated for 1 h) successfully counteracted this induction. Visnagin also enhances PAI-2 transcription in an AHR-dependent manner[1].
In Vivo	Visnagin (10, 30, 60 mg/kg; ip; for 7 days) is effective in reducing plasma amylase and lipase levels and reduces Cerulein (50 μg/kg, six, hourly i.p. injections) induced oxidative stress in male Swiss albino mice (age: 6-8 weeks, weighing 20-25 g)[1]. Visnagin dose dependently decreases the expression of IL-1β, IL-6, TNF-α and IL-17. It attenuates the levels of nuclear p65-NFκB. Visnagin improves the antioxidant defence by improving Nrf2 expression and halts pancreatic inflammation by suppressing NFκB and nitrotyrosine expression in the acinar cells[1].
References	[1]. Radim Vrzal, et al. Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS One. 2013 Sep 19;8(9):e74917. [2]. Lakshmi Priya Pasari, et al. Visnagin attenuates acute pancreatitis via Nrf2/NFκB pathway and abrogates associated multiple organ dysfunction. Biomed Pharmacother. 2019 Apr;112:108629.

Density	1.3±0.1 g/cm3
Boiling Point	378.2±42.0 °C at 760 mmHg
Melting Point	139-142 °C
Molecular Formula	C₁₃H₁₀O₄
Molecular Weight	230.216
Flash Point	182.5±27.9 °C
Exact Mass	230.057907
PSA	52.58000
LogP	2.26
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.613

Visnagin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1420000

CHEMICAL NAME :: 5H-Furo(3,2-g)(1)benzopyran-5-one, 4-methoxy-7-methyl-

CAS REGISTRY NUMBER :: 82-57-5

BEILSTEIN REFERENCE NO. :: 0234955

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H10-O4

MOLECULAR WEIGHT :: 230.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 832 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 7(2),1,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 123 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 7(2),1,1975

Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S3
RTECS	LV1420000

Precursor 9
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DownStream 7
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