Coelonin
Modify Date: 2024-01-08 19:21:48
Coelonin structure
|
Common Name | Coelonin | ||
|---|---|---|---|---|
| CAS Number | 82344-82-9 | Molecular Weight | 242.27000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H14O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of CoeloninCoelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein[1][2]. |
| Name | coelonin |
|---|---|
| Synonym | More Synonyms |
| Description | Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Akt NF-κB IL-1β IL-6 |
| In Vitro | Coelonin (2.5 μg/mL) 显著降低 NF-κB p65 和 p105/50 磷酸化水平[1]。 Coelonin (0-5 μg/mL, 1.5 h) 剂量依赖性地降低 LPS 诱导的 PTEN、AKT 和 IκBa 磷酸化的增加[1]。 Coelonin (10 和 20 μg/ml) 通过减少炎症因子(包括白细胞介素 6 (IL-6) 和肿瘤坏死因子-α (TNF-α)) 的产生来减轻颗粒物 2.5 (PM2.5) 诱导的炎症< sup>[2]. Coelonin 对 IL-1β、IL-6 和 TNF-α 表达的抑制与 PTEN 无关，而对 p27Kip1 降解的抑制导致细胞周期停滞在 G1 期，这依赖于 PTEN[1] . Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 0, 1, 2.5, and 5 μg/mL Incubation Time: 1.5 h Result: Dose dependently reduced the increase of p65 accumulation in the nucleus induced by LPS. Dose dependently reversed LPS-induced iNOS and COX2 expression. LPS (200 ng/mL) significantly increased the phosphorylation of PTEN, AKT and inhibitor of NF-κB (IκBa), which was dose-dependently reduced by coelonin pre-treatment. |
| References |
| Molecular Formula | C15H14O3 |
|---|---|
| Molecular Weight | 242.27000 |
| Exact Mass | 242.09400 |
| PSA | 49.69000 |
| LogP | 2.87200 |
| Storage condition | -20℃ |
| coelin |
| 9,10-dihydro-4-methoxyphenanthrene-2,7-diol |
| 4-methoxy-9,10-dihydrophenanthrene-2,7-diol |
| 2,7-dihydroxy-4-methoxy-9,10-dihydrophenanthrene |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Coelonin
- Price: Negotiable
- Purity: 95.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
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