11-(4-(Hydroxy(oxido)amino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one

Modify Date: 2024-01-11 19:15:51

11-(4-(Hydroxy(oxido)amino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one Structure
11-(4-(Hydroxy(oxido)amino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one structure
Common Name 11-(4-(Hydroxy(oxido)amino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
CAS Number 82408-04-6 Molecular Weight 363.41000
Density 1.31g/cm3 Boiling Point 565.5ºC at 760 mmHg
Molecular Formula C21H21N3O3 Melting Point N/A
MSDS N/A Flash Point 295.8ºC

 Use of 11-(4-(Hydroxy(oxido)amino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one


Antioxidant agent-7 (SD-7) is a benzodiazepine derivative with antioxidant activity with an IC50 value of 470 nM to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical[1].

 Names

Name 9,9-dimethyl-6-(4-nitrophenyl)-6,8,10,11-tetrahydro-5H-benzo[b][1,4]benzodiazepin-7-one
Synonym More Synonyms

  Biological Activity

Description Antioxidant agent-7 (SD-7) is a benzodiazepine derivative with antioxidant activity with an IC50 value of 470 nM to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical[1].
Related Catalog
References

[1]. Bhagat K, et al. Microwave-assisted synthesis of 11-substituted-3,3-dimethyl-2,3,4,5,10,11-hexahydrodibenzo[b,e][1,4]diazepin-1-one derivatives catalysed by silica supported fluoroboric acid as potent antioxidant and anxiolytic agents. Med Chem Res 28, 2200–2217 (2019).

 Chemical & Physical Properties

Density 1.31g/cm3
Boiling Point 565.5ºC at 760 mmHg
Molecular Formula C21H21N3O3
Molecular Weight 363.41000
Flash Point 295.8ºC
Exact Mass 363.15800
PSA 86.95000
LogP 5.61590
Index of Refraction 1.658
Storage condition -20°C

 Synthetic Route

~81%

11-(4-(Hydroxy(oxido)amino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one Structure

11-(4-(Hydroxy(...

CAS#:82408-04-6

Literature: Kolos; Yurchenko; Orlov; Shishkina; Shishkin Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 12 p. 1550 - 1559

~%

11-(4-(Hydroxy(oxido)amino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one Structure

11-(4-(Hydroxy(...

CAS#:82408-04-6

Literature: Kolos; Yurchenko; Orlov; Shishkina; Shishkin Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 12 p. 1550 - 1559

~%

11-(4-(Hydroxy(oxido)amino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one Structure

11-(4-(Hydroxy(...

CAS#:82408-04-6

Literature: Kolos; Yurchenko; Orlov; Shishkina; Shishkin Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 12 p. 1550 - 1559

~%

11-(4-(Hydroxy(oxido)amino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one Structure

11-(4-(Hydroxy(...

CAS#:82408-04-6

Literature: Eynde, J. -J. Vanden; Mayence, A.; Maquestiau, A.; Anders E. Bulletin des Societes Chimiques Belges, 1992 , vol. 101, # 9 p. 801 - 806

~%

11-(4-(Hydroxy(oxido)amino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one Structure

11-(4-(Hydroxy(...

CAS#:82408-04-6

Literature: Eynde, J. -J. Vanden; Mayence, A.; Maquestiau, A.; Anders E. Bulletin des Societes Chimiques Belges, 1992 , vol. 101, # 9 p. 801 - 806

~%

11-(4-(Hydroxy(oxido)amino)phenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one Structure

11-(4-(Hydroxy(...

CAS#:82408-04-6

Literature: Kolos; Yurchenko; Orlov; Shishkina; Shishkin Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 12 p. 1550 - 1559

 Synonyms

MFCD00731281