Nefazodone hydrochloride

Modify Date: 2024-01-02 12:38:17

Nefazodone hydrochloride structure	Common Name	Nefazodone hydrochloride
	CAS Number	82752-99-6	Molecular Weight	506.46800
	Density	N/A	Boiling Point	599.6ºC at 760 mmHg
	Molecular Formula	C₂₅H₃₃Cl₂N₅O₂	Melting Point	186-188ºC
	MSDS	Chinese USA	Flash Point	316.4ºC

Use of Nefazodone hydrochloride

Nefazodone hydrochloride is an antidepressant drug.

Name	nefazodone hydrochloride
Synonym	More Synonyms

Description	Nefazodone hydrochloride is an antidepressant drug.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
References	[1]. Bengi Uslu, et al. Electrochemical characterisation of nefazodone hydrochloride and voltammetric determination of the drug in pharmaceuticals and human serum. Analytica Chimica Acta Volume 462, Issue 1, 26 June 2002, Pages 49–57 [2]. SHEN Wei-Yang, et al. Determination of Nefazodone Hydrochloride Tablets by HPLC. Chinese Journal of Pharmaceuticals, 2003-10

Description

Nefazodone hydrochloride is an antidepressant drug.

Related Catalog

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

References

[1]. Bengi Uslu, et al. Electrochemical characterisation of nefazodone hydrochloride and voltammetric determination of the drug in pharmaceuticals and human serum. Analytica Chimica Acta Volume 462, Issue 1, 26 June 2002, Pages 49–57

[2]. SHEN Wei-Yang, et al. Determination of Nefazodone Hydrochloride Tablets by HPLC. Chinese Journal of Pharmaceuticals, 2003-10

Boiling Point	599.6ºC at 760 mmHg
Melting Point	186-188ºC
Molecular Formula	C₂₅H₃₃Cl₂N₅O₂
Molecular Weight	506.46800
Flash Point	316.4ºC
Exact Mass	505.20100
PSA	55.53000
LogP	4.35680
Storage condition	Desiccate at RT
Water Solubility	DMSO: ~11 mg/mL at 60 °C

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Product Name: Nefazodone HCl
Synonyms:

Section2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:Nefazodone HCl
CAS number:82752-99-6

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not speciﬁed
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C25H32ClN5O2.ClH
Molecular weight:506.5

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

EPT

CAS#:95885-13-5

1-(3-chlorophen...

CAS#:52605-52-4

~63%

Nefazodone hydr...

CAS#:82752-99-6

Literature: Mead Johnson and Company Patent: US4487773 A1, 1984 ; US 4487773 A

Precursor 2
CAS#:95885-13-5 EPT CAS#:52605-52-4 1-(3-chlorophen...
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Nefazodone Hydrochloride