Estradiol-13C2

Modify Date: 2024-01-13 19:24:43

Estradiol-13C2 structure	Common Name	Estradiol-13C2
	CAS Number	82938-05-4	Molecular Weight	274.367
	Density	1.2±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Estradiol-13C2

Estradiol-13C2 (β-Estradiol-13C2) is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

Name	17-beta-Estradiol-13C2
Synonym	More Synonyms

Description	Estradiol-13C2 (β-Estradiol-13C2) is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer Research Areas >> Endocrinology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17(5):1848-59. [3]. Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16(2):595-604. [4]. Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37(1):133. [5]. Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12(7):2549-54. [6]. Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336(2):293-306. [7]. Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160(1):6-12.

Density	1.2±0.1 g/cm3
Molecular Formula	C₁₈H₂₄O₂
Molecular Weight	274.367
Exact Mass	274.184326
Index of Refraction	1.599

(3,4-13C2)-1,3,5(10)-Estratriene-3,17β-diol

(17β)-(3,4-C)Estra-1,3,5(10)-triene-3,17-diol

Estra-1,3,5(10)-triene-3,17-diol-3,4-C, (17β)-

Estradiol-13C2

Use of Estradiol-13C2

Names

Estradiol-13C2 Biological Activity

Chemical & Physical Properties

Synonyms