Leucosceptoside A

Modify Date: 2024-01-11 08:14:36

Leucosceptoside A Structure
Leucosceptoside A structure
Common Name Leucosceptoside A
CAS Number 83529-62-8 Molecular Weight 638.61400
Density 1.545g/cm3 Boiling Point 884.547ºC at 760 mmHg
Molecular Formula C30H38O15 Melting Point N/A
MSDS N/A Flash Point 283.993ºC

 Use of Leucosceptoside A


Leucosceptoside A is a phenylethanoid glycoside with anti-hyperglycemic and anti-hypertensive activities. Leucosceptoside A shows inhibitory activity against α-glucosidase and PKCα (IC50 of 19.0 μM)[1][2][3].

 Names

Name [(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoate

 Leucosceptoside A Biological Activity

Description Leucosceptoside A is a phenylethanoid glycoside with anti-hyperglycemic and anti-hypertensive activities. Leucosceptoside A shows inhibitory activity against α-glucosidase and PKCα (IC50 of 19.0 μM)[1][2][3].
Related Catalog
Target

PKCα:19 μM (IC50)

In Vitro Leucosceptoside A shows weak angiotensin converting enzyme (ACE) inhibitory effect[1]. Leucosceptoside A (4-16 μM) significantly reduces 1-methyl-4-phenylpyridinium ion (MPP+)-induced death of mesencephalic neurons[2].
References

[1]. Chika Ifeanyi Chukwuma, et al. Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review. J Ethnopharmacol. 2019 May 10;235:329-360.

[2]. Yan-Yun Li, et al. Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons. Eur J Pharmacol. 2008 Jan 28;579(1-3):134-40.

[3]. B N Zhou, et al. Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61(11):1410-2.

 Chemical & Physical Properties

Density 1.545g/cm3
Boiling Point 884.547ºC at 760 mmHg
Molecular Formula C30H38O15
Molecular Weight 638.61400
Flash Point 283.993ºC
Exact Mass 638.22100
PSA 234.29000
Index of Refraction 1.664
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