ZK93423

Modify Date: 2024-01-11 16:48:13

ZK93423 Structure
ZK93423 structure
Common Name ZK93423
CAS Number 83910-44-5 Molecular Weight 390.43200
Density 1.269g/cm3 Boiling Point 619.1ºC at 760 mmHg
Molecular Formula C23H22N2O4 Melting Point N/A
MSDS N/A Flash Point 328.2ºC

 Use of ZK93423


ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents[1].

 Names

Name 3-carboethoxy-6-benzyloxy-4-methoxymethyl-β-carboline

 ZK93423 Biological Activity

Description ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents[1].
Related Catalog
In Vivo ZK 93423(0.3-3 mg/kg,i.p.)在 B6C3F 1 品系的雄性小鼠中以 3mg/kg 的剂量引起体温过低[1]。
References

[1]. A H Tang, et al. Antagonism of hypothermia produced by benzodiazepine-related compounds by U-78875 in mice. Eur J Pharmacol. 1993 May 12;236(1):1-5  

 Chemical & Physical Properties

Density 1.269g/cm3
Boiling Point 619.1ºC at 760 mmHg
Molecular Formula C23H22N2O4
Molecular Weight 390.43200
Flash Point 328.2ºC
Exact Mass 390.15800
PSA 73.44000
LogP 4.61820
Index of Refraction 1.658

 Safety Information

HS Code 2933990090

 Synthetic Route

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ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P. Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307

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ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P. Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307

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ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552

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ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P. Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307

~%

ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552

~%

ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552

~%

ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Fryer, R. Ian; Wang, C.-G.; Chia, N.-C.; Basile, A. S.; Gu, Z.-Q.; Skolnick, P. Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 296 - 307

~%

ZK93423 Structure

ZK93423

CAS#:83910-44-5

Literature: Zhang, Haiming; Larock, Richard C. Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9318 - 9330

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%