Urotensin I

Modify Date: 2024-01-02 20:33:18

Urotensin I structure	Common Name	Urotensin I
	CAS Number	83930-33-0	Molecular Weight	4869.46
	Density	1.5±0.1 g/cm3	Boiling Point	1402.8±65.0 °C at 760 mmHg
	Molecular Formula	C₂₁₀H₃₄₀N₆₂O₆₇S₂	Melting Point	N/A
	MSDS	USA	Flash Point	802.2±34.3 °C

Use of Urotensin I

Urotensin I is, 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively.

Name	Urotensin I
Synonym	More Synonyms

Description	Urotensin I is, 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Cardiovascular Disease Peptides
Target	pEC50: 11.46 (human CRF1, CHO cells), 9.36 (human CRF2, CHO cells), 9.85 (rat CRF2α, CHO cells)[1] Ki: 0.4 nM (hCRF1, cell assay), 1.8 nM (rCRF2α, cell assay), and 5.7 nM (mCRF2β, cell assay)[2]
In Vitro	Urotensin I is a 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells[1] and with Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors in cell assay, respectively[2]. Urotensin I exhibits a striking sequence homology with ovine corticotropin-releasing factor and with frog sauvagine, and has potent hypotensive activity and corticotropin-releasing activity[3]. Urotensin I stimulates the release of ACTH from an isolated dispersed goldfish anterior pituitary cell column[4].
References	[1]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35. [2]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33. [3]. Lederis K, et al. Complete amino acid sequence of urotensin I, a hypotensive and corticotropin-releasing neuropeptide from Catostomus. Science. 1982 Oct 8;218(4568):162-5. [4]. Fryer J, et al. Urotensin I, a CRF-like neuropeptide, stimulates acth release from the teleost pituitary. Endocrinology. 1983 Dec;113(6):2308-10.

Density	1.5±0.1 g/cm3
Boiling Point	1402.8±65.0 °C at 760 mmHg
Molecular Formula	C₂₁₀H₃₄₀N₆₂O₆₇S₂
Molecular Weight	4869.46
Flash Point	802.2±34.3 °C
LogP	-4.51
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.669

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Differential expression of corticotropin-releasing factor (CRF) and urotensin I precursor genes, and evidence of CRF gene expression regulated by cortisol in goldfish brain.

Gen. Comp. Endocrinol. 116 , 461-477, (1999)

Corticotropin-releasing factor (CRF) and urotensin I (UI) precursor cDNAs were cloned and sequenced from a goldfish brain cDNA library in order to investigate the distribution of CRF and UI mRNAs in g...

Cardiovascular actions of centrally and peripherally administered trout urotensin-I in the trout.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 , R484-R491, (2000)

The cardiovascular effects of centrally and peripherally administered synthetic trout urotensin (U)-I, a member of the corticotropin-releasing hormone family of neuroendocrine peptides, were investiga...

Singular contributions of fish neuroendocrinology to mammalian regulatory peptide research.

Regul. Pept. 93 , 3-12, (2000)

During the past 20 years, several bioactive peptides have been identified in teleost fishes that subsequently have been shown to play important regulatory roles in mammalian physiology. The urophysis,...

Catostomus urotensin I

H-Asn-Asp-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Asn-Met-Ile-Glu-Met-Ala-Arg-Ile-Glu-Asn-Glu-Arg-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr-Leu-Asp-Glu-Val-NH2

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China
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China
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China
Product Name: Urotensin I
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Contact: Vinnie
Email: Jamie@api-made.com

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Urotensin I

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