Dienestrol

Modify Date: 2024-01-02 10:00:59

Dienestrol Structure
Dienestrol structure
Common Name Dienestrol
CAS Number 84-17-3 Molecular Weight 266.33400
Density 1.129 g/cm3 Boiling Point 395.4ºC at 760 mmHg
Molecular Formula C18H18O2 Melting Point 229ºC
MSDS N/A Flash Point 181.4ºC
Symbol GHS08
GHS08
Signal Word Danger

 Use of Dienestrol


Dienestrol is a synthetic, non-steroidal estrogen, is an estrogen receptor agonist, for the treatment of menopausal and postmenopausal symptoms.

 Names

Name dienestrol
Synonym More Synonyms

 Dienestrol Biological Activity

Description Dienestrol is a synthetic, non-steroidal estrogen, is an estrogen receptor agonist, for the treatment of menopausal and postmenopausal symptoms.
Related Catalog

 Chemical & Physical Properties

Density 1.129 g/cm3
Boiling Point 395.4ºC at 760 mmHg
Melting Point 229ºC
Molecular Formula C18H18O2
Molecular Weight 266.33400
Flash Point 181.4ºC
Exact Mass 266.13100
PSA 40.46000
LogP 4.60460
Index of Refraction 1.4800 (estimate)
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SL0580000
CHEMICAL NAME :
Phenol, 4,4'-(diethylideneethylene)di-
CAS REGISTRY NUMBER :
84-17-3
LAST UPDATED :
199512
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C18-H18-O2
MOLECULAR WEIGHT :
266.36
WISWESSER LINE NOTATION :
QR DYU2&YU2&R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
40 ug/kg
SEX/DURATION :
female 3 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
TYPE OF TEST :
Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
75 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 171,31,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,278,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83633 No. of Facilities: 124 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 2882 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83633 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H350-H361
Precautionary Statements P201-P280-P308 + P313
Hazard Codes Xn: Harmful;
Risk Phrases R40
Safety Phrases S22;S24/25
RIDADR 2811.0
WGK Germany 3
RTECS SL0580000
Hazard Class 6.1

 Articles4

More Articles
Graphene oxide-based microspheres for the dispersive solid-phase extraction of non-steroidal estrogens from water samples.

J. Chromatogr. A. 1368 , 18-25, (2014)

A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method based on the dispersive solid-phase extraction (dSPE) combined with high performance liquid chromatography (HPLC) was develo...

Packed-fiber solid-phase extraction coupled with high performance liquid chromatography–tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 957 , 7-13, (2014)

• A method based on packed-fiber solid-phase extraction (PF SPE) has been established for the determination of three estrogenic stilbenes in dairy products. • Samples were pretreated with PF SPE using...

Quantitative determination of 26 steroids in eggs from various species using liquid chromatography-triple quadrupole-mass spectrometry.

J. Chromatogr. A. 1356 , 54-63, (2014)

A method for analyzing 26 types of steroids in egg matrix was developed. The method used liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in electrospray ionization mode (ESI). T...

 Synonyms

Retalon
Oestrora
Dinestrol
MFCD00050983
Isodienoestrol
Agaldog
Sexadien
Estroral
Dienoestrol
EINECS 201-519-7
Dinovex
Teserene
Restrol
2,4-Hexadiene, 3,4-bis(4-hydroxyphenyl)-
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