ZK-90055 (hydrochloride)

Modify Date: 2024-01-05 17:55:04

ZK-90055 (hydrochloride) Structure
ZK-90055 (hydrochloride) structure
Common Name ZK-90055 (hydrochloride)
CAS Number 84638-81-3 Molecular Weight 342.81800
Density N/A Boiling Point N/A
Molecular Formula C16H23ClN2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ZK-90055 (hydrochloride)


ZK-90055 hydrochloride is a β2 adrenergic receptor agonist.

 Names

Name methyl 4-[2-(tert-butylamino)-1-hydroxyethyl]-7-hydroxy-1H-indole-2-carboxylate,hydrochloride
Synonym More Synonyms

 ZK-90055 (hydrochloride) Biological Activity

Description ZK-90055 hydrochloride is a β2 adrenergic receptor agonist.
Related Catalog
Target

β2 adrenergic receptor[1]

In Vivo Contrasting a pro-drug, a soft-drug is active per se when given locally but is rapidly inactivated when it reaches the general circulation. Thus, a long duration of action at a minimum of systemic side effects may be achieved after inhalation of a h2-agonist designed in this way. One such example is ZK-90055, an indol derivative with a hydrolysable ester bond on the ring system. The development of ZK-90055 is stopped before clinical trials are commenced[2].
References

[1]. Waldeck B, et al. beta-Adrenoceptor agonists after terbutaline. Pharmacol Toxicol. 1995;77 Suppl 3:25-9.

[2]. Waldeck B, et al. Beta-adrenoceptor agonists and asthma--100 years of development. Eur J Pharmacol. 2002 Jun 7;445(1-2):1-12.

 Chemical & Physical Properties

Molecular Formula C16H23ClN2O4
Molecular Weight 342.81800
Exact Mass 342.13500
PSA 94.58000
LogP 3.27450
Storage condition 2-8℃

 Synonyms

ZK-90055 (hydrochloride)
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