Isoastragaloside I

Modify Date: 2024-01-01 21:17:55

Isoastragaloside I structure	Common Name	Isoastragaloside I
	CAS Number	84676-88-0	Molecular Weight	869.044
	Density	1.4±0.1 g/cm3	Boiling Point	920.6±65.0 °C at 760 mmHg
	Molecular Formula	C₄₅H₇₂O₁₆	Melting Point	N/A
	MSDS	N/A	Flash Point	264.7±27.8 °C

Use of Isoastragaloside I

Isoastragaloside I is a natural compound from the medicinal herb Radix Astragali; possesses the activity of elevating adiponectin production.IC50 value:Target:Astragaloside II and isoastragaloside I selectively increased adiponectin secretion in primary adipocytes without any obvious effects on a panel of other adipokines. Furthermore, an additive effect on induction of adiponectin production was observed between these two compounds and rosiglitazone, a thiazolidinedione class of insulin-sensitizing drugs. Chronic administration of astragaloside II and isoastragaloside I in both dietary and genetic obese mice significantly elevated serum levels of total adiponectin and selectively increased the composition of its high molecular weight oligomeric complex.

Name	isoastragaloside I
Synonym	More Synonyms

Description	Isoastragaloside I is a natural compound from the medicinal herb Radix Astragali; possesses the activity of elevating adiponectin production.IC50 value:Target:Astragaloside II and isoastragaloside I selectively increased adiponectin secretion in primary adipocytes without any obvious effects on a panel of other adipokines. Furthermore, an additive effect on induction of adiponectin production was observed between these two compounds and rosiglitazone, a thiazolidinedione class of insulin-sensitizing drugs. Chronic administration of astragaloside II and isoastragaloside I in both dietary and genetic obese mice significantly elevated serum levels of total adiponectin and selectively increased the composition of its high molecular weight oligomeric complex.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Natural Products >> Terpenoids and Glycosides
References	[1]. Xu A, et al. Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology. 2009 Feb;150(2):625-33.

Density	1.4±0.1 g/cm3
Boiling Point	920.6±65.0 °C at 760 mmHg
Molecular Formula	C₄₅H₇₂O₁₆
Molecular Weight	869.044
Flash Point	264.7±27.8 °C
Exact Mass	868.482056
PSA	240.36000
LogP	2.03
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.596
Storage condition	-20°C