EX-527 R-enantiomer

Modify Date: 2024-06-09 22:34:25

EX-527 R-enantiomer Structure
EX-527 R-enantiomer structure
Common Name EX-527 R-enantiomer
CAS Number 848193-69-1 Molecular Weight 248.708
Density 1.4±0.1 g/cm3 Boiling Point 531.7±38.0 °C at 760 mmHg
Molecular Formula C13H13ClN2O Melting Point N/A
MSDS N/A Flash Point 275.4±26.8 °C

 Use of EX-527 R-enantiomer


Selisistat R-enantiomer (EX-527 R-enantiomer) is much less active R-enantiomer of Selisistat, with an IC50 of > 100 μM for SIRT1.

 Names

Name (1R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Synonym More Synonyms

 EX-527 R-enantiomer Biological Activity

Description Selisistat R-enantiomer (EX-527 R-enantiomer) is much less active R-enantiomer of Selisistat, with an IC50 of > 100 μM for SIRT1.
Related Catalog
Target

IC50: > 100 μM (SIRT1)[1]

References

[1]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 531.7±38.0 °C at 760 mmHg
Molecular Formula C13H13ClN2O
Molecular Weight 248.708
Flash Point 275.4±26.8 °C
Exact Mass 248.071640
LogP 2.22
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.688
Storage condition 2-8℃

 Synonyms

(1R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
1H-Carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro-, (1R)-
EX-527 R-enantiomer
EX-527 (R-enantiomer)
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Price: $462/10mM*1mLinDMSO

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