Alogliptin benzoate

Modify Date: 2024-01-02 15:59:58

Alogliptin benzoate Structure
Alogliptin benzoate structure
 Common Name Alogliptin benzoate
CAS Number 850649-62-6 Molecular Weight 461.513
Density N/A Boiling Point 671.2ºC at 760 mmHg
Molecular Formula C25H27N5O4 Melting Point N/A
MSDS N/A Flash Point 359.7ºC

 Use of Alogliptin benzoate


Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.IC50 value: <10 nMTarget: DPP4Alogliptin is an orally administered, anti-diabetic drug in the DPP-4 inhibitor class. A randomized clinical trial reporting in 2011 aimed to determine the efficacy and safety of alogliptin versus placebo and voglibose among newly diagnosed Type 2 diabetes patients in Japan. The main outcome indicated that alogliptin was statistically superior to both comparitors. A randomized clinical trial reporting in 2012 aimed to demonstrate that alogliptin was "non-inferior" to a "very low fat/calorie traditional Japanese diet" among newly diagnosed Type 2 diabetes patients in Japan. The outcome indicated that both the drug and dietary treatments comparably impacted indicators of the diabetic condition, such as HbA1c levels and glycemic efficacy. The drug treatment had its impact without changing body mass index (BMI), but the dietary treatment was accompanied by a significant reduction in the BMI…

 Names

Name alogliptin benzoate
Synonym More Synonyms

 Alogliptin benzoate Biological Activity

Description Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.IC50 value: <10 nMTarget: DPP4Alogliptin is an orally administered, anti-diabetic drug in the DPP-4 inhibitor class. A randomized clinical trial reporting in 2011 aimed to determine the efficacy and safety of alogliptin versus placebo and voglibose among newly diagnosed Type 2 diabetes patients in Japan. The main outcome indicated that alogliptin was statistically superior to both comparitors. A randomized clinical trial reporting in 2012 aimed to demonstrate that alogliptin was "non-inferior" to a "very low fat/calorie traditional Japanese diet" among newly diagnosed Type 2 diabetes patients in Japan. The outcome indicated that both the drug and dietary treatments comparably impacted indicators of the diabetic condition, such as HbA1c levels and glycemic efficacy. The drug treatment had its impact without changing body mass index (BMI), but the dietary treatment was accompanied by a significant reduction in the BMI…
Related Catalog
References

[1]. Rendell M, et al. Alogliptin benzoate for the treatment of type 2 diabetes. Expert Opin Pharmacother. 2012 Mar;13(4):553-63.

[2]. Radha Andukuri, et al. Alogliptin: a new addition to the class of DPP-4 inhibitors. Diabetes Metab Syndr Obes. 2009; 2: 117-126.

[3]. Takeuchi K, et al. Pharmacological and clinical profile of alogliptin benzoate (NESINA?).Nihon Yakurigaku Zasshi. 2011 Jan;137(1):43-50.

[4]. Moritoh Y, et al. Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice.Eur J Pharmacol. 2008 Jul 7;588(2-3):325-32.

 Chemical & Physical Properties

Boiling Point 671.2ºC at 760 mmHg
Molecular Formula C25H27N5O4
Molecular Weight 461.513
Flash Point 359.7ºC
Exact Mass 461.206299
PSA 134.35000
LogP 2.54458

 Synonyms

Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, benzoate (1:1)
2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile,benzoic acid
SYR 322
Vipidia (TN)
Alogliptin (Benzoate)
Alogliptin benzoate
2-({6-[(3R)-3-Amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)benzonitrile benzoate (1:1)
2-({6-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile benzoate (1:1)
alogliptin monobenzoate
Nesina
2-[6-[3(R)-Aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-ylmethyl]benzonitrile benzoate
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Alogliptin benzoate suppliers

Price: $79/10mM*1mLinDMSO

Reference only. check more Alogliptin benzoate price

Related Compounds: More...
Alogliptin benzoate
115545-85-2
Alogliptin benzoate impurity L
887417-88-1
Alogliptin benzoate impurity F
1704940-35-1
Alogliptin benzoate impurity K
1618644-32-8
Alogliptin-d3
1133421-35-8
Alogliptin hydrochloride
1246610-75-2
Alogliptin Related CoMpound 5
1338677-76-1
Alogliptin
850649-61-5
Alogliptin Related Compound 15
1108731-49-2
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
3-(5-Chlorothiophen-3-yl)-4,4,4-trifluorobutanoic acid
2229278-51-5
(1S)-1-(4-ethoxy-2-methylphenyl)-2,2,2-trifluoroethan-1-ol
2227782-34-3
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
tert-Butyl-DL-alanine
1375289-11-4
Chemsrc provides Alogliptin benzoate(CAS#:850649-62-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Alogliptin benzoate are included as well.>> amp version: Alogliptin benzoate

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved