Gaboxadol hydrochloride

Modify Date: 2024-01-09 10:41:02

Gaboxadol hydrochloride Structure
Gaboxadol hydrochloride structure
Common Name Gaboxadol hydrochloride
CAS Number 85118-33-8 Molecular Weight 176.601
Density N/A Boiling Point 295.7ºC at 760 mmHg
Molecular Formula C6H9ClN2O2 Melting Point 236 °C
MSDS USA Flash Point 132.6ºC

 Use of Gaboxadol hydrochloride


Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a selective agonist at GABAA receptors that contain α4-δ subunits, and has anxiolytic and sedative effects[1].

 Names

Name 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol Hydrochloride
Synonym More Synonyms

 Gaboxadol hydrochloride Biological Activity

Description Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a selective agonist at GABAA receptors that contain α4-δ subunits, and has anxiolytic and sedative effects[1].
Related Catalog
Target

GABAA[1]

References

[1]. Zanettini C, et al. Comparing the discriminative stimulus effects of modulators of GABAA receptors containing α4-δ subunits with those of gaboxadol in rats. Psychopharmacology (Berl). 2016 May;233(10):2005-13.

 Chemical & Physical Properties

Boiling Point 295.7ºC at 760 mmHg
Melting Point 236 °C
Molecular Formula C6H9ClN2O2
Molecular Weight 176.601
Flash Point 132.6ºC
Exact Mass 176.035248
PSA 58.03000
LogP 0.74440

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
RTECS NY3396800

 Articles9

More Articles
Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.

J. Neurosci. 34(31) , 10361-78, (2014)

The enteric nervous system (ENS) provides the intrinsic neural control of the gastrointestinal tract (GIT) and regulates virtually all GI functions. Altered neuronal activity within the ENS underlies ...

Effect of nucleus accumbens shell infusions of ganaxolone or gaboxadol on ethanol consumption in mice.

Psychopharmacol. Ser. 232(8) , 1415-26, (2015)

Allopregnanolone (ALLO) is an endogenous neuroactive steroid thought to alter the reinforcement value of alcohol (ethanol) due to its actions as a positive modulator of the GABAA receptor (GABAAR). Ex...

Effects of gaboxadol on the expression of cocaine sensitization in rats.

Exp. Clin. Psychopharmacol. 24 , 131-41, (2016)

Behavioral sensitization to psychostimulants is associated with changes in dopamine (DA), glutamate, and GABA within the mesocorticolimbic and nigrostriatal DA systems. Because GABAA receptors are hig...

 Synonyms

Gaboxadol hydrochloride
Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, hydrochloride (1:1)
4,5,6,7-Tetrahydro[1,2]oxazolo[5,4-c]pyridin-3(2H)-one hydrochloride (1:1)
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