JNJ-18038683 free base
Modify Date: 2024-04-01 17:10:41
JNJ-18038683 free base structure
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Common Name | JNJ-18038683 free base | ||
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| CAS Number | 851373-91-6 | Molecular Weight | 337.846 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 547.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H20ClN3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 285.0±30.1 °C | |
Use of JNJ-18038683 free baseJNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays; decreases 5-HT (100 nM)-stimulated adenylyl cyclase in rat and human 5-HT7/HEK293 cells with pKb of 8.01 and 7.99, respectively; shows 10-fold selectivity over h5-HT6 receptor, 15-fold selectivity over rat adrenergic α1 receptor, 14- to 25-fold selectivity over the h5-HT2 receptor subtypes, and 20-fold selectivity over h5-HT1B receptor; prolongs rapid eye movement (REM) sleep and decreases REM duration induced by citalopram in vivo. |
| Name | JNJ-18038683 FREE BASE |
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| Synonym | More Synonyms |
| Description | JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays; decreases 5-HT (100 nM)-stimulated adenylyl cyclase in rat and human 5-HT7/HEK293 cells with pKb of 8.01 and 7.99, respectively; shows 10-fold selectivity over h5-HT6 receptor, 15-fold selectivity over rat adrenergic α1 receptor, 14- to 25-fold selectivity over the h5-HT2 receptor subtypes, and 20-fold selectivity over h5-HT1B receptor; prolongs rapid eye movement (REM) sleep and decreases REM duration induced by citalopram in vivo. |
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| References | References 1. Bonaventure P, et al. J Pharmacol Exp Ther. 2012 Aug;342(2):429-40. 2. Shelton J, et al. Front Behav Neurosci. 2015 Jan 15;8:453. View Related Products by Target Histamine Receptor |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 547.6±50.0 °C at 760 mmHg |
| Molecular Formula | C20H20ClN3 |
| Molecular Weight | 337.846 |
| Flash Point | 285.0±30.1 °C |
| Exact Mass | 337.134583 |
| LogP | 3.84 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.656 |
| Pyrazolo[3,4-d]azepine, 3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydro-1-(phenylmethyl)- |
| 1-Benzyl-3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine |
| JNJ-18038683 FREE BASE |