145903-06-6
145903-06-6 structure
- Name: JTV-519 free base
- Chemical Name: 3-(4-benzylpiperidin-1-yl)-1-(7-methoxy-3,5-dihydro-2H-1,4-benzothiazepin-4-yl)propan-1-one
- CAS Number: 145903-06-6
- Molecular Formula: C25H32N2O2S
- Molecular Weight: 424.59900
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
- Create Date: 2017-11-21 14:24:15
- Modify Date: 2024-01-09 20:18:24
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JTV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Cardioprotective agent[1].
| Name | 3-(4-benzylpiperidin-1-yl)-1-(7-methoxy-3,5-dihydro-2H-1,4-benzothiazepin-4-yl)propan-1-one |
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| Synonyms |
K201 free base
JTV-519 hemifumarate 4-[3-(4-Benzylpiperidin-1-yl)propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine K201 UNII-EBY0ENK2GQ K21 JTV 519 |
| Description | JTV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Cardioprotective agent[1]. |
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| Related Catalog | |
| References |
| Density | 1.153 g/cm3 |
|---|---|
| Boiling Point | 615.133ºC at 760 mmHg |
| Molecular Formula | C25H32N2O2S |
| Molecular Weight | 424.59900 |
| Flash Point | 325.821ºC |
| Exact Mass | 424.21800 |
| PSA | 58.08000 |
| LogP | 4.35010 |
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~%
145903-06-6 |
| Literature: Marks, Andrew R.; Landry, Donald W.; Deng, Shi Xian; Cheng, Zhen Zhuang Patent: US2005/215540 A1, 2005 ; Location in patent: Page/Page column 37 ; |
| Precursor 2 | |
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| DownStream 0 | |