HLY78

Modify Date: 2024-01-02 17:57:11

HLY78 Structure
HLY78 structure
Common Name HLY78
CAS Number 854847-61-3 Molecular Weight 267.32200
Density N/A Boiling Point N/A
Molecular Formula C17H17NO2 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS09
GHS09
Signal Word Warning

 Use of HLY78


HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1].

 Names

Name 4-ethyl-5-methyl-8,9-methylenedioxy-5,6-dihydrophenantridine
Synonym More Synonyms

 HLY78 Biological Activity

Description HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1].
Related Catalog
Target

Wnt/β-catenin[1]

References

[1]. Wang S, et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85.

 Chemical & Physical Properties

Molecular Formula C17H17NO2
Molecular Weight 267.32200
Exact Mass 267.12600
PSA 21.70000
LogP 3.65950

 Safety Information

Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H410
Precautionary Statements P273-P501
Hazard Codes N
RIDADR UN 3077 9 / PGIII

 Synonyms

4-ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
4-Aethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridin
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