Tedizolid structure
|
Common Name | Tedizolid | ||
---|---|---|---|---|
CAS Number | 856866-72-3 | Molecular Weight | 370.338 | |
Density | 1.6±0.1 g/cm3 | Boiling Point | 614.5±65.0 °C at 760 mmHg | |
Molecular Formula | C17H15FN6O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 325.4±34.3 °C |
Use of TedizolidTedizolid is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome. |
Name | tedizolid |
---|---|
Synonym | More Synonyms |
Description | Tedizolid is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome. |
---|---|
Related Catalog | |
In Vitro | Tedizolid (0.25 μg/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP[1]. |
In Vivo | For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema[1]. |
Animal Admin | To induce a systemic S. pneumoniae infection, male ICR mice (weight, 18 to 20 g) are inoculated intraperitoneally with 1 of 4 PRSP isolates (DR9, DR10, DR11, or DR14) suspended in 10% mucin. The suspension contained sufficient bacteria to kill 100% of untreated control mice. At 1 h postinfection, mice receives a single dose of either tedizolid phosphate or linezolid, and survival is assessed daily for 7 days postinfection. Treatments are delivered both orally and intravenously at each of four doses (40 mg/kg of body weight, 13.33 mg/kg, 4.44 mg/kg, and 1.48 mg/kg), with 8 mice per group defined by dose, delivery method, and infecting strain. The 50% effective dose (ED50), i.e., the dose allowing survival of 50% of the infected mice, is calculated for each delivery route using probit analysis. |
References |
Density | 1.6±0.1 g/cm3 |
---|---|
Boiling Point | 614.5±65.0 °C at 760 mmHg |
Molecular Formula | C17H15FN6O3 |
Molecular Weight | 370.338 |
Flash Point | 325.4±34.3 °C |
Exact Mass | 370.118958 |
PSA | 106.26000 |
LogP | 1.56 |
Vapour Pressure | 0.0±1.9 mmHg at 25°C |
Index of Refraction | 1.725 |
HS Code | 29339900 |
---|
~84% Tedizolid CAS#:856866-72-3 |
Literature: TRIUS THERAPEUTICS; COSTELLO, Carrie, A.; SIMSON, Jaqueline, A.; DUGUID, Robert, J.; PHILLIPSON, Douglas Patent: WO2010/42887 A2, 2010 ; Location in patent: Page/Page column 19-20 ; |
~% Tedizolid CAS#:856866-72-3 |
Literature: European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1027 - 1039 |
~% Tedizolid CAS#:856866-72-3 |
Literature: European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1027 - 1039 |
(5R)-3-{3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl}-5-(hydroxymethyl)-1,3-oxazolidin-2-one |
Torezolid |
TR-701 |
(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one |
TR-700 |
(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one |
Tedizolid [USAN:INN] |
2-Oxazolidinone, 3-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-(hydroxymethyl)-, (5R)- |
UNII:97HLQ82NGL |
Tedizolid |
(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-5-(hydroxymethyl)-2-oxazolidinone |