TP-051

Modify Date: 2024-01-06 16:23:00

TP-051 Structure
TP-051 structure
Common Name TP-051
CAS Number 858097-86-6 Molecular Weight 526.62
Density N/A Boiling Point N/A
Molecular Formula C29H31FO6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TP-051


TP-051 is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes[1].

 Names

Name TP-051

 TP-051 Biological Activity

Description TP-051 is a potent FFAR1 agonist with an Ki value of 16 nM for human FFAR1. TP-051 can increase insulin secretion in rat insulinoma cells. TP-051 can be used to research type 2 diabetes[1].
Related Catalog
Target

Ki: 16 nM (human FFAR1)[1]

In Vitro TP-051 (compound 31) (0.01-10 μM; 2 h; INS-1 cells) augments insulin secretion in a dose-dependent manner in the presence of 11 mM glucose and statistically significant increases in insulin secretion were observed at doses of above 0.1 μM of the compound[1].
References

[1]. Mikami S, et al. Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes. J Med Chem. 2012 Apr 26;55(8):3756-76.

 Chemical & Physical Properties

Molecular Formula C29H31FO6S
Molecular Weight 526.62
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