Calcitonin C-Terminal Flanking Peptide (human) trifluoroacetate salt

Modify Date: 2024-01-02 08:10:15

Calcitonin C-Terminal Flanking Peptide (human) trifluoroacetate salt structure	Common Name	Calcitonin C-Terminal Flanking Peptide (human) trifluoroacetate salt
	CAS Number	85916-47-8	Molecular Weight	2436.60000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉₇H₁₅₄N₃₄O₃₆S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Calcitonin C-Terminal Flanking Peptide (human) trifluoroacetate salt

Katacalcin is a second potent plasma calcium-lowering peptide.

Name	Katacalcin
Synonym	More Synonyms

Description	Katacalcin is a second potent plasma calcium-lowering peptide.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Peptides
In Vitro	Katacalcin is a potent plasma calcium lowering peptide. Katacalcin belongs to the calcitonin family, that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of these ions in the bones[1]. Katacalcin (KC) belongs to a small family of polypeptides that are encoded by the calc-1 gene and also include calcitonin (CT) and procalcitonin NH2-terminal cleavage peptide (N-ProCT). Katacalcin pretreatment leads to a concentration-dependent decrease at concentrations between 1 amol/liter and 10 fmol/liter and is a more potent inhibitor of fMLP-induced chemotaxis than CT or procalcitonin (PCT). Katacalcin deactivates CD14+ peripheral blood mononuclear cell (PBMC) chemotaxis not only toward N-formyl-Met-Leu-Phe (fMLP) but also toward other attractants of the chemokine family (heterologous deactivation) as well as toward PCT and CT. Pretreatment of CD14+ PBMCs with Katacalcin also deactivates subsequent chemotaxis toward Katacalcin itself. Katacalcin elicites concentration-dependent migration of CD14+ PBMC at concentrations from the atomolar to the micromolar range and deactivates attractant-induced chemotaxis. Katacalcin regulates human CD14+ PBMC migration via signaling events involving protein kinase A-dependent cAMP pathways[2].
Kinase Assay	Leukocyte migration is measured using a modified 48-blind well microchemotaxis chamber equipped with 5 μm pore-sized nitrocellulose filters for CD14+ PBMC chemotaxis. In some experiments cells are incubated for 20 minutes with GFX (500 nM), Staurosporine (10 ng/mL), Tyrphostin-23 (10 ng/mL), Wortmannin (WTN) (10 nmol/liter), Protein kinase A inhibitor (PKI) (from 0.1 to 100 ng/mL) or Rp-cAMPS (from 100 pM to 100 μM), or CTX (1 nM) or pertussis toxin (PTX) (1 nM). For determination of Katacalcin 's potency to deactivate CD14+ PBMC chemotaxis toward fMLP, cells are incubated with Katacalcin (from 1 amol/liter to 1 μmol/liter) for 20 minutes. For control, cAMP-independent migration of CD14+ PBMC toward bombesin is tested in some of the experiments. After washing twice, 50 μL of a cell suspension (1×106 cells/mL) is put into the upper compartment of the chemotaxis chamber and cells are allowed to migrate for 90 minutes toward peptides derived from the calc-1 gene in the lower wells. After these migration periods, the filters are dehydrated, fixed, and stained with hematoxylin and eosin. Migration depth is quantified by microscopy, measuring the distance from the surface of the filter to the leading front of three cells migration[2].
References	[1]. Hillyard CJ, et al. Katacalcin: a new plasma calcium-lowering hormone. Lancet. 1983 Apr 16;1(8329):846-8. [2]. Kaneider NC, et al. Involvement of cyclic adenosine monophosphate-dependent protein kinase A and pertussis toxin-sensitive G proteins in the migratory response of human CD14⁺ mononuclear cells tokatacalcin. J Bone Miner Res. 2002 Oct;17(10):1872-82.

Molecular Formula	C₉₇H₁₅₄N₃₄O₃₆S₂
Molecular Weight	2436.60000
Exact Mass	2435.07000
PSA	1198.66000
Storage condition	2-8℃

Pdn-21

Calcitonin carboxyl-terminal flanking peptide

hCCAP

CCP I

Human ccap

CCAP

Peptide (aspartic acid-asparagine)

Preprocalcitonin carboxyl-terminal region peptide

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CALCITONINC-TERMINALFLANKINGPEPTIDE(HUMAN)
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

GL Biochem (Shanghai) Ltd.
China
Product Name: Katacalcin
Price: $Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: Calcitonin C-Terminal Flanking Peptide (human) trifluoroacetate salt
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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