IM-54
Modify Date: 2024-01-07 19:20:34
IM-54 structure
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Common Name | IM-54 | ||
|---|---|---|---|---|
| CAS Number | 861891-50-1 | Molecular Weight | 325.405 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 511.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C19H23N3O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 263.1±30.1 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of IM-54IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death[1][2]. |
| Name | 1-methyl-3-(1-methylindol-3-yl)-4-(pentylamino)pyrrole-2,5-dione |
|---|---|
| Synonym | More Synonyms |
| Description | IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | IM-54 selectively inhibits oxidative stress-induced necrosis, but it does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis[1]. IM-54 shows strong inhibition of H2O2-induced necrosis, with an IC50 of 0.25 μM against HL-60 cells treated with H2O2[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 511.5±50.0 °C at 760 mmHg |
| Molecular Formula | C19H23N3O2 |
| Molecular Weight | 325.405 |
| Flash Point | 263.1±30.1 °C |
| Exact Mass | 325.179016 |
| PSA | 54.34000 |
| LogP | 3.81 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.615 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
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Dynamin-related protein Drp1 and mitochondria are important for Shigella flexneri infection.
Int. J. Med. Microbiol. 304(5-6) , 530-41, (2014) Shigella infection in epithelial cells induces cell death which is accompanied by mitochondrial dysfunction. In this study the role of the mitochondrial fission protein, Drp1 during Shigella infection... |
| IM-54 |
| Necrosis Inhibitor,IM-54 |
| 1-Methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)-1H-pyrrole-2,5-dione |
| 1H-Pyrrole-2,5-dione, 1-methyl-3-(1-methyl-1H-indol-3-yl)-4-(pentylamino)- |
| IN1208 |